Research Library

Total article count: 618

Addiction

• Adolescent Exposure to Chronic Delta-9-Tetrahydrocannabinol Blocks Opiate Dependence in Maternally Deprived Rats
• Cannabidiol, a Nonpsychotropic Component of Cannabis, Inhibits Cue-Induced Heroin Seeking and Normalizes Discrete Mesolimbic Neuronal Disturbances
• Cannabidiol as an Intervention for Addictive Behaviors: A Systematic Review of the Evidence
• Cannabis as a substitute for alcohol and other drugs
• Interactions between delta9-tetrahydrocannabinol and heroin: self-administration in rhesus monkeys
• Involvement of the endocannabinoid system in drug addiction
• Medical Cannabis Laws and Opioid Analgesic Overdose Mortality in the United States, 1999-2010

Alzheimer's/Dementia

• A Molecular Link Between the Active Component of Marijuana and Alzheimer's Disease Pathology
• Activity of muscarinic, galanin and cannabinoid receptors in the prodromal and advanced stages in the triple transgenic mice model of Alzheimer's disease
• Cannabinoids and Dementia: A Review of Clinical and Preclinical Data
• Cannabinoids for the treatment of dementia
• Cannabinoids for treatment of Alzheimer’s disease: moving toward the clinic
• Cannabidiol and other cannabinoids reduce microglial activation in vitro and in vivo: relevance to Alzheimer's disease
• Delta-9-tetrahydrocannabinol for nighttime agitation in severe dementia
• Natural Phytochemicals in the Treatment and Prevention of Dementia: An Overview
• Stimulation of brain glucose uptake by cannabinoid CB2 receptors and its therapeutic potential in Alzheimer’s disease
• Synthetic cannabinoids in dementia with agitation: case studies and literature review
• The influence of cannabinoids on generic traits of neurodegeneration
• The role of endocannabinoid signaling in the molecular mechanisms of neurodegeneration in Alzheimer's disease

Antibacterial

• Antibacterial activity of Δ9-­tetrahydrocannabinol and cannabidiol
• Antibacterial Cannabinoids from Cannabis sativa: A Structure-Activity Study
• Antimicrobial Activity of Cannabis sativa L.
• Essential oils of different cultivars of Cannabis sativa L. and their antimicrobial activity
• Extraction of cannabinoids from cannabis sativa L plant and its potential antimicrobial activity
• In vitro antibacterial activity of Cannabis sativa leaf extracts to some selective pathogenicbacterial strains
• Marijuana, Tetrahydrocannabinol, and Pulmonary Antibacterial Defenses

Antioxidant

• Cannabidiol and (−)Δ9-tetrahydrocannabinol are neuroprotective antioxidants
• Cannabidiol as an Emergent Therapeutic Strategy for Lessening the Impact of Inflammation on Oxidative Stress
• Cannabidiol Post-Treatment Alleviates Rat Epileptic-Related Behaviors and Activates Hippocampal Cell Autophagy Pathway Along with Antioxidant Defense in Chronic Phase of Pilocarpine-Induced Seizure
• Cannabidiol protects liver from binge alcohol-induced steatosis by mechanisms including inhibition of oxidative stress and increase in autophagy
• Mechanism for inhibitory effect of cannabidiol on microsomal testosterone oxidation in male rat liver
• Neuroprotective antioxidants from marijuana
• Oxyradical Stress, Endocannabinoids, and Atherosclerosis
• Prospects for cannabinoid therapies in basal ganglia disorders
• Protective effects of Δ9-tetrahydrocannabinol against N-methyl-D-aspartate-induced AF5 cell death

Antiprion

• Nonpsychoactive Cannabidiol Prevents Prion Accumulation and Protects Neurons against Prion Toxicity

Anxiety

• Action of Cannabidiol on the Anxiety and Other Effects Produced by D9-THC in Normal Subjects
• Antidepressant-Like and Anxiolytic-Like Effects of Cannabidiol: A Chemical Compound of Cannabis sativa
• Cannabidiol, a Cannabis sativa constituent, as an anxiolytic drug
• Cannabinoid-related agents in the treatment of anxiety disorders- current knowledge and future perspectives
• Chronic blockade of cannabinoid CB2 receptors induces anxiolytic-like actions associated with alterations in GABA(A) receptors
• Effects of Cannabidiol (CBD) on Regional Cerebral Blood
• Distinct Effects of Δ9-Tetrahydrocannabinol and Cannabidiol on Neural Activation During Emotional Processing
• Neural basis of anxiolytic effects of cannabidiol (CBD) in generalized social anxiety disorder: a preliminary report
• Overexpression of CB2 cannabinoid receptors decreased vulnerability to anxiety and impaired anxiolytic action of alprazolam in mice

Appetite

• Endocannabinoids, feeding and suckling – from our perspective
• Endogenous cannabinoid system as a modulator of food intake
• Hypothalamic POMC neurons promote cannabinoid-induced feeding
• The cannabinoids: An overview. Therapeutic implications in vomiting and nausea after cancer chemotherapy, in appetite promotion, in multiple sclerosis and in neuroprotection

Arthritis

• Cannabinoid CB2 Receptors Regulate Central Sensitization and Pain Responses Associated with Osteoarthritis of the Knee Joint
• Cannabinoid receptor 2 as a potential therapeutic target in rheumatoid arthritis
• Cannabinoid WIN-55,212-2 mesylate inhibits interleukin-1b induced matrix metalloproteinase and tissue inhibitor of matrix metalloproteinase expression in human chondrocytes
• Characterisation of the Cannabinoid Receptor System in Synovial Tissue and Fluid in Patients With Osteoarthritis and Rheumatoid Arthritis

Asthma

• Evaluation of Serum Cytokines Levels and the Role of Cannabidiol Treatment in Animal Model of Asthma

Attention Deficit Hyperactivity Disorder (ADHD)

• Association of the Cannabinoid Receptor Gene (CNR1) With ADHD and Post-Traumatic Stress Disorder
• Cannabis improves symptoms of ADHD
• Cannabinoid-induced conditioned place preference in the spontaneously hypertensive rat–an animal model of attention deficit hyperactivity disorder
• Drug Reinforcement in a Rat Model of Attention Deficit-Hyperactivity Disorder – The Spontaneously Hypertensive Rat (SHR)
• Methods of the Pharmacological Imaging of the Cannabinoid System (PhICS) study: towards understanding the role of the brain endocannabinoid system in human cognition

Autism

• Alterations in the endocannabinoid system in the rat valproic acid model of autism
• Autism-Associated Neuroligin-3 Mutations Commonly Disrupt Tonic Endocannabinoid Signaling
• Cannabinoid Receptor Type 2, but not Type 1, is Up-Regulated in Peripheral Blood Mononuclear Cells of Children Affected by Autistic Disorders
• Consequences of Cannabinoid and Monoaminergic System Disruption in a Mouse Model of Autism Spectrum Disorders
• Deficient Social and Play Behavior in Juvenile and Adult Rats after Neonatal Cortical Lesion: Effects of Chronic Pubertal Cannabinoid Treatment
• Endocannabinoid System as Novel Therapeutic Target for Autism Treatment
• Method for predicting autism spectrum disorders by cannabinoid and cannabinoid receptor expression
• Species differences in cannabinoid receptor 2 (CNR2 gene): identification of novel human and rodent CB2 isoforms, differential tissue expression and regulation by cannabinoid receptor ligands
• Use of dronabinol (delta-9-THC) in autism: A prospective single-case-study with an early infantile autistic child
• Uncoupling of the endocannabinoid signaling complex in a mouse model of fragile X syndrome
• Variation in the human cannabinoid receptor CNR1 gene modulates gaze duration for happy faces

Autoimmune

• Cannabidiol Arrests Onset of Autoimmune Diabetes in NOD Mice
• Cannabinoids as novel anti-inflammatory drugs
• Role of myeloid-derived suppressor cells in amelioration of experimental autoimmune hepatitis following activation of TRPV1 receptors by cannabidiol

Batten Disease

• Cannabidiol provides long-lasting protection against the deleterious effects of inflammation in a viral model of multiple sclerosis: A role for A2A receptors
• Cannabidiol Reduces Aβ-Induced Neuroinflammation and Promotes Hippocampal Neurogenesis through PPARγ Involvement
• Cannabidiol reduces host immune response and prevents cognitive impairments in Wistar rats submitted to pneumococcal meningitis
• Cannabidiol reduces lipopolysaccharide-induced vascular changes and inflammation in the mouse brain: an intravital microscopy study
• Cannabinoid inhibits HIV-1 Tat-stimulated adhesion of human monocyte-like cells to extracellular matrix proteins
• siRNA knockdown of GPR18 receptors in BV-2 microglia attenuates N-arachidonoyl glycineinduced cell migration

Breast Cancer

• Antitumor Activity of Plant Cannabinoids with Emphasis on the Effect of Cannabidiol on Human Breast Carcinoma
• Cannabidiol as a novel inhibitor of Id-1 gene expression in aggressive breast cancer cells
• Cannabidiol Induces Programmed Cell Death in Breast Cancer Cells by Coordinating the Cross-talk between Apoptosis and Autophagy
• Cannabinoids: A new hope for breast cancer therapy
• Cannabinoids reduce ErbB2-driven breast cancer progression through Akt inhibition
• Modulation of breast cancer cell viability by a cannabinoid receptor 2 agonist, JWH-015, is calcium dependent
• Pathways mediating the effects of cannabidiol on the reduction of breast cancer cell proliferation, invasion, and metastasis.
• Synthetic cannabinoid receptor agonists inhibit tumor growth and metastasis of breast cancer
• Targeting multiple cannabinoid anti-tumour pathways with a resorcinol derivative leads to inhibition of advanced stages of breast cancer
• The endogenous cannabinoid anandamide inhibits human breast cancer cell proliferation

Cancer

• A cannabinoid quinone inhibits angiogenesis by targeting vascular endothelial cells
• A pilot clinical study of Δ9-tetrahydrocannabinol in patients with recurrent glioblastoma multiforme
• Anandamide Induces Apoptosis in Human Cells via Vanilloid Receptors
• Antiangiogenic activity of the endocannabinoid anandamide: Correlation to its tumor-suppressor efficacy
• Anticancer mechanisms of cannabinoids
• Anti-proliferative effects of anandamide in human hepatocellular carcinoma cells
• Anti-tumoral action of cannabinoids: Involvement of sustained ceramide accumulation and extracellular signal-regulated kinase activation
• Anti-tumoral action of cannabinoids on hepatocellular carcinoma: role of AMPK-dependent activation of autophagy
• Antitumor Activity of Plant Cannabinoids with Emphasis on the Effect of Cannabidiol on Human Breast Carcinoma
• Antitumorigenic Effects of Cannabinoids beyond Apoptosis
• Cannabidiol (CBD) Priming Enhances Cisplatin Killing Of Cancer Cells
• Cannabidiol Enhances the Inhibitory Effects of Δ9-Tetrahydrocannabinol on Human Glioblastoma Cell Proliferation and Survival
• Cannabidiol as potential anticancer drug
• Cannabidiol Inhibits Cancer Cell Invasion Via Upregulation Of Tissue Inhibitor Of Matrix Metalloproteinases-1
• Cannabidiol Inhibits Growth and Induces Programmed Cell Death in Kaposi Sarcoma–Associated Herpesvirus Infected Endothelium
• Cannabidiol inhibits lung cancer cell invasion and metastasis via intercellular adhesion molecule-1
• Cannabinoid-associated cell death mechanisms in tumor models (Review)
• Cannabinoid receptor 1 is a potential drug target for treatment of translocation-positive rhabdomyosarcoma
• Cannabinoid Receptor Agonist as an Alternative Drug in 5-Fluorouracil-resistant Gastric Cancer Cells
• Cannabinoid receptor ligands as potential anticancer agents – high hopes for new therapies
• Cannabinoid Receptor-Mediated Apoptosis Induced by R()-Methanandamide and Win55,212-2 Is Associated with Ceramide Accumulation and p38 Activation in Mantle Cell Lymphoma
• Cannabinoid receptors as novel targets for the treatment of melanoma
• Cannabinoid Receptors, CB1 and CB2, as Novel Targets for Inhibition of Non-Small Cell Lung Cancer Growth and Metastasis
• Cannabinoids and Cancer
• Cannabinoids and cancer: pros and cons of an antitumour strategy
• Cannabinoids and ceramide: Two lipids acting hand-by-hand
• Cannabinoids and omega-3/6 endocannabinoids as cell death and anticancer modulators
• Cannabinoids as therapeutic agents in cancer: current status and future implications
• Cannabinoids, Endocannabinoids and Cancer
• Cannabinoids for Cancer Treatment: Progress and Promise
• Cannabinoids induce apoptosis of pancreatic tumor cells via endoplasmic reticulum stress-related genes
• Cannabinoids: potential antitumoral agents
• Cannabinoids Protect Astrocytes from Ceramide-induced Apoptosis through the Phosphatidylinositol 3-Kinase/Protein Kinase B Pathway
• Cannabinoids selectively inhibit proliferation and induce death of cultured human glioblastoma multiforme cells
• Cannabis and Cannabinoids (PDQ®) - National Cancer Institute
• Cannabis Extract Treatment for Terminal Acute Lymphoblastic Leukemia with a Philadelphia Chromosome Mutation
• Cannabis in Cancer Care
• CBD inhibits angiogenesis by multiple mechanisms
• Ceramide: a new second messenger of cannabinoid action
• Clinical Significance of Cannabinoid Receptors CB1 and CB2 Expression in Human Malignant and Benign Thyroid Lesions
• COX-2 and PPAR-g Confer Cannabidiol-Induced Apoptosis of Human Lung Cancer Cells
• Δ9-Tetrahydrocannabinol inhibits epithelial growth factor-induced lung cancer cell migration in vitro as well as its growth and metastasis in vivo
• Differential role of cannabinoids in the pathogenesis of skin cancer
• Endocannabinoids and Cancer
• Endocannabinoids and fatty acid amides in cancer inflammation and related disorders
• Endocannabinoids as emerging suppressors of angiogenesis and tumor invasion (Review)
• Endocannabinoids as Guardians of Metastasis
• Endocannabinoids in endocrine and related tumours
• Enhancing the Activity of Cannabidiol and Other Cannabinoids In Vitro Through Modifications to Drug Combinations and Treatment Schedules
• Evaluation of the Cyclooxygenase Inhibiting Effects of Six Major Cannabinoids Isolated from Cannabis sativa
• Exogenous hepatitis B virus envelope proteins induce endoplasmic reticulum stress: involvement of cannabinoid axis in liver cancer cells
• Expression and Functional Relevance of Cannabinoid Receptor 1 in Hodgkin Lymphoma
• Expression of cannabinoid receptors type 1 and type 2 in non-Hodgkin lymphoma: Growth inhibition by receptor activation
• High level of cannabinoid receptor 1, absence of regulator of G protein signalling 13 and differential expression of Cyclin D1 in mantle cell lymphoma
• Id-1 Is a Key Transcriptional Regulator of Glioblastoma Aggressiveness and a Novel Therapeutic Target
• In vitro and in vivo efficacy of non-psychoactive cannabidiol in neuroblastoma
• Increasing Antiproliferative Properties of Endocannabinoids in N1E-115 Neuroblastoma Cells through Inhibition of Their Metabolism
• Inhibition of Cancer Cell Invasion by Cannabinoids via Increased Expression of Tissue Inhibitor of Matrix Metalloproteinases-1
• Inhibition of skin tumor growth and angiogenesis in vivo by activation of cannabinoid receptors
• Inhibition of tumor angiogenesis by cannabinoids
• Integrating cannabis into clinical cancer care
• Involvement of PPARc in the antitumoral action of cannabinoids on hepatocellular carcinoma
• Loss of Cannabinoid Receptor 1 Accelerates Intestinal Tumor Growth
• Marijuana Use and the Risk of Lung and Upper Aerodigestive Tract Cancers: Results of a Population-Based Case-Control Study
• Medical marijuana for cancer
• Microarray and Pathway Analysis Reveal Distinct Mechanisms Underlying Cannabinoid-Mediated Modulation of LPS-Induced Activation of BV-2 Microglial Cells
• Non-THC cannabinoids inhibit prostate carcinoma growth in vitro and in vivo: pro-apoptotic effects and underlying mechanisms
• Potentiation of Cannabinoid-Induced Cytotoxicity in Mantle Cell Lymphoma through Modulation of Ceramide Metabolism
• Potentiation of the antitumor activity of adriamycin against osteosarcoma by cannabinoid WIN-55,212-2
• Preparation and characterisation of biodegradable microparticles filled with THC and their antitumor efficacy on cancer cell lines
• Proapoptotic effect of endocannabinoids in prostate cancer cells
• Receptor-dependent and receptor-independent endocannabinoid signaling: A therapeutic target for regulation of cancer growth
• Synthetic cannabinoid receptor agonists inhibit tumor growth and metastasis of breast cancer
• Targeting CB2-GPR55 Receptor Heteromers Modulates Cancer Cell Signaling
• Targeting CB2 cannabinoid receptors as a novel therapy to treat malignant lymphoblastic disease
• The Antitumor Activity of Plant-Derived Non-Psychoactive Cannabinoids
• The CB2 cannabinoid receptor signals apoptosis via ceramide-dependent activation of the mitochondrial intrinsic pathway
• The effects of cannabidiol and its synergism with bortezomib in multiple myeloma cell lines. A role for transient receptor potential vanilloid type-2
• The endocannabinoid system and cancer: therapeutic implication
• The endocannabinoid system in cancer- Potential therapeutic target?
• The endogenous cannabinoid anandamide inhibits human breast cancer cell proliferation
• The Expression Level of CB1 and CB2 Receptors Determines Their Efficacy at Inducing Apoptosis in Astrocytomas
• The potential relevance of the endocannabinoid, 2- arachidonoylglycerol, in diffuse large B-cell lymphoma
• The role of cannabinoids in prostate cancer: Basic science perspective and potential clinical applications
• The stress-regulated protein p8 mediates cannabinoid-induced apoptosis of tumor cells
• The use of cannabinoids as anticancer agents
• Towards the use of cannabinoids as antitumour agents
• United States patent application publication for phytocannabinoids in the treatment of cancer

Cannabidiol (CBD)

• Action of Cannabidiol on the Anxiety and Other Effects Produced by D9-THC in Normal Subjects
• Cannabidiol displays unexpectedly high potency as an antagonist of CB1 and CB2 receptor agonists in vitro
• Cannabidiol: from an inactive cannabinoid to a drug with wide spectrum of action
• Cannabidiol in Humans—The Quest for Therapeutic Targets
• Cannabidiol is a negative allosteric modulator of the type 1 cannabinoid receptor
• Cannabidiol: Promise and Pitfalls
• Identification of Psychoactive Degradants of Cannabidiol in Simulated Gastric and Physiological Fluid
• Safety and Side Effects of Cannabidiol, a Cannabis sativa Constituent

CBDV

• Cannabidivarin (CBDV) suppresses pentylenetetrazole (PTZ)-induced increases in epilepsy-related gene expression
• Cannabidivarin-rich cannabis extracts are anticonvulsant in mouse and rat via a CB1 receptor-independent mechanism

Cardiovascular

• Acute administration of cannabidiol in vivo suppresses ischaemia-induced cardiac arrhythmias and reduces infarct size when given at reperfusion
• Blood pressure regulation by endocannabinoids and their receptors
• Cannabinoids in experimental stroke: a systematic review and meta-analysis
• Cyclooxygenase metabolism mediates vasorelaxation to 2-arachidonoylglycerol (2-AG) in human mesenteric arteries
• Is the cardiovascular system a therapeutic target for cannabidiol?
• Oxyradical Stress, Endocannabinoids, and Atherosclerosis
• Role of Endocannabinoids and Cannabinoid-1 Receptors in Cerebrocortical Blood Flow Regulation
• STUDIES INVESTIGATING THE MECHANISMS OF THE CARDIOPROTECTIVE EFFECTS OF CANNABIDIOL
• Therapeutic Potential of Non-Psychotropic Cannabidiol in Ischemic Stroke

CB1 Receptor

• Allosteric Modulation of the Cannabinoid CB1 Receptor
• Cannabidiol is a negative allosteric modulator of the type 1 cannabinoid receptor
• Cannabinoid CB1 receptor binding and acetylcholinesterase inhibitory activity of Sceletium tortuosum L.
• Cannabinoid Receptors, CB1 and CB2, as Novel Targets for Inhibition of Non-Small Cell Lung Cancer Growth and Metastasis
• Design, Synthesis, Biological Properties, and Molecular Modeling Investigations of Novel Tacrine Derivatives with a Combination of Acetylcholinesterase Inhibition and Cannabinoid CB1 Receptor Antagonism
• Enhanced acetylcholine release in the hippocampus of cannabinoid
• Evidence for functional CB1 cannabinoid receptor expressed in the rat thyroid
• Immunohistochemical analysis of cannabinoid receptor 1 expression in steatotic rat livers
• Loss of Cannabinoid Receptor 1 Accelerates Intestinal Tumor Growth
• Presynaptically Located CB1 Cannabinoid Receptors Regulate GABA Release from Axon Terminals of Specific Hippocampal Interneurons

CB2 Receptor

• Cannabinoid Type 2 Receptors Mediate a Cell Type Specific Plasticity in the Hippocampus
• CB2 cannabinoid receptors as an emerging target for demyelinating diseases: from neuroimmune interactions to cell replacement strategies
• Direct suppression of autoreactive lymphocytes in the central nervous system via the CB2 receptor
• Non-psychoactive CB2 cannabinoid agonists stimulate neural progenitor proliferation
• Targeting CB2 receptors and the endocannabinoid system for the treatment of pain
• The CB2 cannabinoid receptor signals apoptosis via ceramide-dependent activation of the mitochondrial intrinsic pathway

Cellular Function

• Cannabidiol is a Potent Inhibitor of the Catalytic Activity of Cytochrome P450 2C19
• Cannabidiol Targets Mitochondria to Regulate Intracellular Ca2 Levels
• Characterization of P-glycoprotein Inhibition by Major Cannabinoids from Marijuana

Cerebral Palsy

• Survey Results of Pain Treatments in Adults with Cerebral Palsy

Cognition

• Cannabidiol reduces host immune response and prevents cognitive impairments in Wistar rats submitted to pneumococcal meningitis
• Effects of cannabis on cognitive function in patients with multiple sclerosis
• Keep off the grass Cannabis? Cognition and addiction
• Methods of the Pharmacological Imaging of the Cannabinoid System (PhICS) study: towards understanding the role of the brain endocannabinoid system in human cognition

Colon Cancer

• Cannabinoid receptor activation induces apoptosis through tumor necrosis factor alpha-mediated ceramide de novo synthesis in colon cancer cells
• Chemopreventive effect of the non-psychotropic phytocannabinoid cannabidiol on experimental colon cancer
• Estrogenic induction of cannabinoid CB1 receptor in human colon cancer cell lines
• Growth inhibition and induction of apoptosis in colorectal tumor cells by cyclooxygenase inhibitors
• Induction of Apoptosis by Cannabinoids in Prostate and Colon Cancer Cells Is Phosphatase Dependent
• Inhibition of colon carcinogenesis by a standardized Cannabis sativa extract with high content of cannabidiol
• Possible endocannabinoid control of colorectal cancer growth
• The cannabinoid δ9-tetrahydrocannabinol inhibits RAS-MAPK and PI3K-AKT survival signalling and induces BAD-mediated apoptosis in colorectal cancer cells
• The endogenous cannabinoid, anandamide, induces cell death in colorectal carcinoma cells: a possible role for cyclooxygenase 2
• The endogenous cannabinoid, anandamide, induces COX-2-dependent cell death in apoptosis-resistant colon cancer cells

Crohn's Disease

• Cannabis Alleviates Symptoms Of Crohn’s Disease
• Cannabis Finds Its Way into Treatment of Crohn’s Disease
• Cannabis Induces a Clinical Response in Patients With Crohn’s Disease: A Prospective Placebo-Controlled Study
• Treatment of Crohn’s Disease with Cannabis: An Observational Study

D9-Tetrahydrocannabinol (THC)

• A pilot clinical study of Δ9-tetrahydrocannabinol in patients with recurrent glioblastoma multiforme
• A tale of two cannabinoids: The therapeutic rationale for combining tetrahydrocannabinol and cannabidiol
• Activity of cannabis in relation to its delta'-trans-tetrahydro-cannabinol content
• Adolescent Exposure to Chronic Delta-9-Tetrahydrocannabinol Blocks Opiate Dependence in Maternally Deprived Rats
• Antibacterial activity of Δ9-­tetrahydrocannabinol and cannabidiol
• Antidepressant-like effect of Δ9-tetrahydrocannabinol and other cannabinoids isolated from Cannabis sativa L
• BRONCHODILATOR EFFECT OF Δ1-TETRAHYDROCANNABINOL
• Cannabidiol and (−)Δ9-tetrahydrocannabinol are neuroprotective antioxidants
• Cannabidiol Attenuates the Appetitive Effects of Δ9-Tetrahydrocannabinol in Humans Smoking Their Chosen Cannabis
• Cannabidiol Enhances the Inhibitory Effects of Δ9-Tetrahydrocannabinol on Human Glioblastoma Cell Proliferation and Survival
• D9-Tetrahydrocannabinol inhibits epithelial growth factor-induced lung cancer cell migration in vitro as well as its growth and metastasis in vivo
• D9-Tetrahydrocannabinol Prevents Methamphetamine-Induced Neurotoxicity
• Dose-related differences in the regional pattern of cannabinoid receptor adaptation and in vivo tolerance development to delta9-tetrahydrocannabinol
• Effect of Δ-9-Tetrahydrocannabinol and Cannabidiol on Nocturnal Sleep and Early-Morning Behavior in Young Adults
• Fatty Acid Binding Proteins (FABPs) are Intracellular Carriers for Δ9-Tetrahydrocannabinol (THC) and Cannabidiol (CBD)
• Histone Modifications Are Associated with Delta (9)-tetrahydrocannabinol-Mediated Alterations in Antigen-Specific T Cell Responses
• Influence of Treatment of Tourette Syndrome with Δ9-Tetrahydrocannabinol (Δ9-THC) on Neuropsychological Performance
• Long-­term behavioral and biochemical effects of an ultra-­low dose of Δ9-­tetrahydrocannabinol (THC): neuroprotection and ERK signaling
• Marijuana, Tetrahydrocannabinol, and Pulmonary Antibacterial Defenses
• Neuroprotection by Δ9-Tetrahydrocannabinol, the Main Active Compound in Marijuana, against Ouabain-Induced In Vivo Excitotoxicity
• Neuroprotective Effect of(−)Δ9-Tetrahydrocannabinol and Cannabidiol in N-Methyl-d-Aspartate-Induced Retinal Neurotoxicity
• Opposite Effects of D-9-Tetrahydrocannabinol and Cannabidiol on Human Brain Function and Psychopathology
• Preliminary, open-­label, pilot study of add-­on oral Δ9-­tetrahydrocannabinol in chronic post-­traumatic stress disorder
• Protective effects of Δ9-tetrahydrocannabinol against N-methyl-D-aspartate-induced AF5 cell death
• The diverse CB1 and CB2 receptor pharmacology of three plant cannabinoids: Δ9-tetrahydrocannabinol, cannabidiol and Δ9-tetrahydrocannabivarin
• The effects of Δ9-tetrahydrocannabinol and cannabidiol alone and in combination on damage, inflammation and in vitro motility disturbances in rat colitis
• The endocannabinoid system and emotional Processing: A pharmacological fMRI study with Δ9-tetrahydrocannabinol
• Treatment of Tourette-Syndrome with Δ9-Tetrahydrocannabinol (THC): a randomized crossover trial

D9-Tetrahydrocannabinolic acid (THCA)

• Can You Pass the Acid Test? Critical Review and Novel Therapeutic Perspectives of D9-Tetrahydrocannabinolic Acid A.pdf

Depression

• Antidepressant-Like and Anxiolytic-Like Effects of Cannabidiol: A Chemical Compound of Cannabis sativa
• Antidepressant-like effect of Δ9-tetrahydrocannabinol and other cannabinoids isolated from Cannabis sativa L
• Cannabinoids promote embryonic and adult hippocampus neurogenesis and produce anxiolytic- and antidepressant-like effects

Diabetes

• Cannabidiol Arrests Onset of Autoimmune Diabetes in NOD Mice
• Cannabidiol attenuates cardiac dysfunction, oxidative stress, fibrosis, and inflammatory and cell death signaling pathways in diabetic cardiomyopathy
• Cannabinoids Regulate Bcl-2 and Cyclin D2 Expression in Pancreatic β Cells
• Effects of the cannabinoid-1 receptor blocker rimonabant on weight reduction and cardiovascular risk factors in overweight patients: 1-year experience from the RIO-Europe study
• Novel Study Reports Marijuana Users Have Better Blood Sugar Control
• Presence of functional cannabinoid receptors in human endocrine pancreas
• The Endocannabinoid System and Plant-Derived Cannabinoids in Diabetes and Diabetic Complications
• The endocannabinoid system in obesity and type 2 diabetes
• The Endogenous Cannabinoid System Stimulates Glucose Uptake in Human Fat Cells via Phosphatidylinositol 3-Kinase and Calcium Dependent Mechanisms

Drug Interactions

• A Phase I, open-label, randomized, crossover study in three parallel groups to evaluate the effect of Rifampicin, Ketoconazole, and Omeprazole on the pharmacokinetics of THC/CBD oromucosal spray in healthy volunteers
• Cannabis and its effect on anesthesia

Edema

• Sex differences in anti-allodynic, anti-hyperalgesic and anti-edema effects of Δ9-tetrahydrocannabinol in the rat

Emesis

• Cannabidiol, a non-psychotropic component of cannabis, attenuates vomiting and nausea-like behaviour via indirect agonism of 5-HT1A somatodendritic autoreceptors in the dorsal raphe nucleus
• Cannabidiolic acid prevents vomiting in Suncus murinus and nausea-induced behaviour in rats by enhancing 5-HT1A receptor activation
• Interaction between non-psychotropic cannabinoids in marihuana: effect of cannabigerol (CBG) on the anti-nausea or anti-emetic effects of cannabidiol (CBD) in rats and shrews
• Regulation of nausea and vomiting by cannabinoids
• The effects of cannabidiol and tetrahydrocannabinol on motion-induced emesis in Suncus murinus
• The Nonpsychoactive Cannabinoid Cannabidiol Inhibits 5-Hydroxytryptamine3A Receptor-Mediated Currents in Xenopus laevis Oocytes

Endocannabinoid System (ECS)

• Agonistic Properties of Cannabidiol at 5-HT1a Receptors
• Antiangiogenic activity of the endocannabinoid anandamide: Correlation to its tumor-suppressor efficacy
• Biphasic Effects of Cannabinoids on Acetylcholine Release in the Hippocampus: Site and Mechanism of Action
• Cannabidiol displays unexpectedly high potency as an antagonist of CB1 and CB2 receptor agonists in vitro
• Cannabidiol is an allosteric modulator at mu- and delta-opioid receptors
• Cannabinoid control of brain bioenergetics: Exploring the subcellular localization of the CB1 receptor
• Cannabinoid-induced mesenteric vasodilation through an endothelial site distinct from CB1 or CB2 receptors
• Cannabinoid pharmacology: the first 66 years
• Cannabinoid Receptors and Endocannabinoids: Evidence for New Players
• Cannabinoid Receptors CB1 and CB2 Form Functional Heteromers in Brain
• Cannabis and endocannabinoid modulators: Therapeutic promises and challenges
• Cannabis, a complex plant: different compounds and different effects on individuals
• Care and Feeding of the Endocannabinoid System: A Systematic Review of Potential Clinical Interventions that Upregulate the Endocannabinoid System
• Clinical Endocannabinoid Deficiency (CECD): Can this Concept Explain Therapeutic Benefits of Cannabis in Migraine, Fibromyalgia, Irritable Bowel Syndrome and other Treatment-Resistant Conditions
• Clinical endocannabinoid deficiency (CECD) revisited: Can this concept explain the therapeutic benefits of cannabis in migraine, fibromyalgia, irritable bowel syndrome and other treatment-resistant conditions
• Clinical Endocannabinoid Deficiency Reconsidered: Current Research Supports the Theory in Migraine, Fibromyalgia, Irritable Bowel, and Other Treatment-Resistant Syndromes
• Dose-related differences in the regional pattern of cannabinoid receptor adaptation and in vivo tolerance development to delta9-tetrahydrocannabinol
• Endocannabinoid binding to the cannabinoid receptors: what is known and what remains unknown
• Endocannabinoid CB1 receptor-mediated rises in Ca2+ and depolarization-induced suppression of inhibition
• Endocannabinoid signalling and the deteriorating brain
• Endocannabinoid Signaling Regulates Sleep Stability
• Endocannabinoids and energy homeostasis: An update
• Endothelium-dependent metabolism by endocannabinoid hydrolases and cyclooxygenases limits vasorelaxation to anandamide and 2-arachidonoylglycerol
• Enhanced discriminative stimulus effects of 9-THC in the presence of cannabidiol and 8-OH-DPAT in rhesus monkeys
• Estrogen Receptor Beta and 2-arachidonoylglycerol Mediate the Suppressive Effects of Estradiol on Frequency of Postsynaptic Currents in Gonadotropin-Releasing Hormone Neurons of Metestrous Mice: An Acute Slice Electrophysiological Study
• Evidence for a physiological role of endocannabinoids in the modulation of seizure threshold and severity
• Evidence that the plant cannabinoid cannabigerol is a highly potent a2-adrenoceptor agonist and moderately potent 5HT1A receptor antagonist
• Fatty Acid Binding Proteins (FABPs) are Intracellular Carriers for Δ9-Tetrahydrocannabinol (THC) and Cannabidiol (CBD)
• Hardwiring the Brain: Endocannabinoids Shape Neuronal Connectivity
• Identification of cytochrome P450 enzymes responsible for metabolism of cannabidiol by human liver microsomes
• Mitochondria: a possible nexus for the regulation of energy homeostasis by the endocannabinoid system
• Modulating the endocannabinoid system in human health and disease: successes and failures
• Neuropharmacology of the Endocannabinoid Signaling System-Molecular Mechanisms, Biological Actions and Synaptic Plasticity
• Pharmacokinetics and metabolism of the plant cannabinoids, delta9-tetrahydrocannabinol, cannabidiol and cannabinol
• Recent advances in cannabinoid receptor agonists and antagonists
• Role of the Cannabinoid System in Pain Control and Therapeutic Implications for the Management of Acute and Chronic Pain Episodes
• Role of the Endocannabinoid System in the Neuroendocrine Responses to Inflammation
• Targeting the endocannabinoid system with cannabinoid receptor agonists- pharmacological strategies and therapeutic possibilities
• The diverse CB1 and CB2 receptor pharmacology of three plant cannabinoids: Δ9-tetrahydrocannabinol, cannabidiol and Δ9-tetrahydrocannabivarin
• The Emerging Role of the Endocannabinoid System in Endocrine Regulation and Energy Balance
• The Endocannabinoid-CB Receptor System: Importance for development and in pediatric disease
• The endocannabinoid system and migraine
• The Endocannabinoid System as an Emerging Target of Pharmacotherapy
• The Endocannabinoid System, Cannabinoids, and Pain
• The endocannabinoid system drives neural progenitor proliferation
• The endocannabinoid system in normal and pathological brain ageing
• The endogenous cannabinoid system and its role in nociceptive behavior
• The orphan receptor GPR55 is a novel cannabinoid receptor
• The therapeutic potential of novel cannabinoid receptors

Endocrine System

• Estrogen Receptor Beta and 2-arachidonoylglycerol Mediate the Suppressive Effects of Estradiol on Frequency of Postsynaptic Currents in Gonadotropin-Releasing Hormone Neurons of Metestrous Mice: An Acute Slice Electrophysiological Study
• Estrogenic induction of cannabinoid CB1 receptor in human colon cancer cell lines
• Gynecomastia and cannabis smoking A nonassociation among US Army soldiers
• Presence of functional cannabinoid receptors in human endocrine pancreas
• The effects of delta9-tetrahydrocannabinol and cannabidiol on the metabolism of gonadal steroids in the rat
• The Emerging Role of the Endocannabinoid System in Endocrine Regulation and Energy Balance

Epilepsy

• Activation of the Cannabinoid Type-1 Receptor Mediates the Anticonvulsant Properties of Cannabinoids in the Hippocampal Neuronal Culture Models of Acquired Epilepsy and Status Epilepticus
• Analysis of endocannabinoid signaling elements and related proteins in lymphocytes of patients with Dravet syndrome
• Assessment of the role of CB receptors in cannabinoid 1 anticonvulsant effects
• Cannabidiol displays antiepileptiform and antiseizure properties in vitro and in vivo
• Cannabidiol exerts anti-convulsant effects in animal models of temporal lobe and partial seizures
• Cannabidiol: Pharmacology and potential therapeutic role in epilepsy and other neuropsychiatric disorders
• Cannabidiol Post-Treatment Alleviates Rat Epileptic-Related Behaviors and Activates Hippocampal Cell Autophagy Pathway Along with Antioxidant Defense in Chronic Phase of Pilocarpine-Induced Seizure
• Cannabidiol Rescues Acute Hepatic Toxicity and Seizure Induced by Cocaine
• Cannabidivarin (CBDV) suppresses pentylenetetrazole (PTZ)-induced increases in epilepsy-related gene expression
• Cannabidivarin is anticonvulsant in mouse and rat
• Cannabidivarin-rich cannabis extracts are anticonvulsant in mouse and rat via a CB1 receptor-independent mechanism
• Cannabinoids for pediatric epilepsy? Up in smoke or real science?
• Cannabinoids in the Treatment of Epilepsy
• Cannabis, Cannabinoids and Tinnitus
• CANNABIS IN THE MANAGEMENT AND TREATMENT OF SEIZURES AND EPILEPSY: A SCIENTIFIC REVIEW
• CBD-enriched medical cannabis for intractable pediatric epilepsy; The current Israeli experience
• Chronic Administration of Cannabidiol to Healthy Volunteers and Epileptic Patients
• Epidiolex (Cannabidiol) in Treatment Resistant Epilepsy
• Evidence for a physiological role of endocannabinoids in the modulation of seizure threshold and severity
• Marijuana Use in Epilepsy: The Myth and the Reality
• On the application of cannabis in paediatrics and epileptology
• Redistribution of CB1 Cannabinoid Receptors in the Acute and Chronic Phases of Pilocarpine-Induced Epilepsy
• Report of a parent survey of cannabidiol-enriched cannabis use in pediatric treatment-resistant epilepsy
• The case for assessing cannabidiol in epilepsy
• The case for medical marijuana in epilepsy
• The current status of artisanal cannabis for the treatment of epilepsy in the United States
• The Endogenous Cannabinoid System Regulates Seizure Frequency and Duration in a Model of Temporal Lobe Epilepsy
• Understanding Cannabinoids and Epilepsy
• Voltage-gated sodium (NaV) channel blockade by plant cannabinoids does not confer anticonvulsant effects per se

Fibromyalgia

• Association of Herbal Cannabis Use With Negative Psychosocial Parameters in Patients With Fibromyalgia
• Marijuana Rated Most Effective for Treating Fibromyalgia

Fibrosis

Gastrointestinal Disease

• Beneficial effect of the non-psychotropic plant cannabinoid cannabigerol on experimental inflammatory bowel disease
• Cannabidiol in Inflammatory Bowel Diseases: A Brief Overview
• Cannabidiol Reduces Intestinal Inflammation through the Control of Neuroimmune Axis
• Cannabinoids and the gastrointestinal tract
• Cannabinoids for gastrointestinal diseases: potential therapeutic applications
• Cannabis Alleviates Symptoms Of Crohn’s Disease
• Cannabis Finds Its Way into Treatment of Crohn’s Disease
• Cannabis Induces a Clinical Response in Patients With Crohn’s Disease: A Prospective Placebo-Controlled Study
• Cannabis use amongst patients with inflammatory bowel disease
• Ghrelin and cannabinoids require the ghrelin receptor to affect cellular energy metabolism
• Marijuana Use Patterns Among Patients with Inflammatory Bowel Disease
• Pro-resolution, protective and anti-nociceptive effects of a cannabis extract in the rat gastrointestinal tract
• The effects of Δ9-tetrahydrocannabinol and cannabidiol alone and in combination on damage, inflammation and in vitro motility disturbances in rat colitis
• Treatment of Crohn’s Disease with Cannabis: An Observational Study

General

• Cannabidiol: from an inactive cannabinoid to a drug with wide spectrum of action
• Cannabinoids in health and disease
• Cannabis sativa: The Plant of the Thousand and One Molecules
• Chemical constituents of marijuana: The complex mixture of natural cannabinoids
• Early phytocannabinoid chemistry to endocannabinoids and beyond
• Future of Cannabis and Cannabinoids in Therapeutics
• Medical Marijuana: Clearing Away the Smoke
• Non-psychotropic plant cannabinoids: new therapeutic opportunities from an ancient herb
• Pharmacological actions and therapeutic uses of cannabis and cannabinoids
• Phytocannabinoids beyond the Cannabis plant – do they exist?
• Plant cannabinoids: a neglected pharmacological treasure trove
• Review on clinical studies with cannabis and cannabinoids 2010-2014
• Safety and Toxicology of Cannabinoids
• Therapeutic aspects of cannabis and cannabinoids
• Therapeutic Benefits of Cannabis: A Patient Survey
• The Therapeutic Potential of Cannabis and Cannabinoids
• Toward Drugs Derived from Cannabis

Glaucoma

• Cannabinoids and glaucoma
• Neuroprotective Effect of(−)Δ9-Tetrahydrocannabinol and Cannabidiol in N-Methyl-d-Aspartate-Induced Retinal Neurotoxicity

Glioblastoma

• A pilot clinical study of Δ9-tetrahydrocannabinol in patients with recurrent glioblastoma multiforme
• Cannabidiol Enhances the Inhibitory Effects of Δ9-Tetrahydrocannabinol on Human Glioblastoma Cell Proliferation and Survival
• Cannabinoids selectively inhibit proliferation and induce death of cultured human glioblastoma multiforme cells
• Delta 9-tetrahydrocannabinol inhibits cell cycle progression by downregulation of E2F1 in human glioblastoma multiforme cells
• Id-1 Is a Key Transcriptional Regulator of Glioblastoma Aggressiveness and a Novel Therapeutic Target

Glioma

• A Combined Preclinical Therapy of Cannabinoids and Temozolomide against Glioma
• Antitumor Effects of Cannabidiol, a Nonpsychoactive Cannabinoid, on Human Glioma Cell Lines
• Cannabidiol, a Non-Psychoactive Cannabinoid Compound, Inhibits Proliferation and Invasion in U87-MG and T98G Glioma Cells through a Multitarget Effect
• Cannabidiol inhibits human glioma cell migration through a cannabinoid receptor-independent mechanism
• Cannabinoid action induces autophagy-mediated cell death through stimulation of ER stress in human glioma cells
• Cannabinoids as potential new therapy for the treatment of gliomas
• Cannabinoids Inhibit Glioma Cell Invasion by Down-regulating Matrix Metalloproteinase-2 Expression
• Cannabinoids Inhibit the Vascular Endothelial Growth Factor Pathway in Gliomas
• Δ9-Tetrahydrocannabinol induces apoptosis in C6 glioma cells
• Inhibition of Glioma Growth in Vivo by Selective Activation of the CB2 Cannabinoid Receptor
• Safety and efficacy of a novel cannabinoid chemotherapeutic, KM-233, for the treatment of high-grade glioma
• Systematic review of the literature on clinical and experimental trials on the antitumor effects of cannabinoids in gliomas
• The Combination of Cannabidiol and D9 -Tetrahydrocannabinol Enhances the Anticancer Effects of Radiation in an Orthotopic Murine Glioma Model

HIV

• Cannabinoid inhibits HIV-1 Tat-stimulated adhesion of human monocyte-like cells to extracellular matrix proteins

Huntington's Disease

• Structure, expression and regulation of the cannabinoid receptor gene (CB1) in Huntington's disease transgenic mice
• The pattern of neurodegeneration in Huntington's disease: a comparative study of cannabinoid, dopamine, adenosine and GABAA receptor alterations in the human basal ganglia in Huntington's disease

Immune Function

• Cannabidiol reduces host immune response and prevents cognitive impairments in Wistar rats submitted to pneumococcal meningitis
• Cannabinoid-induced apoptosis in immune cells as a pathway to immunosuppression
• Cannabinoid receptor activation leads to massive mobilization of myeloid-derived suppressor cells with potent immunosuppressive properties
• Cannabinoids and the immune system
• Cannabinoids and the immune system: Potential for the treatment of inflammatory diseases
• Cannabinoids, Immune System and Cytokine Network
• CB2 cannabinoid receptors as an emerging target for demyelinating diseases: from neuroimmune interactions to cell replacement strategies
• D9-Tetrahydrocannabinol-Induced Apoptosis in the Thymus and Spleen as a Mechanism of Immunosuppression in Vitro and in Vivo
• Expression of central and peripheral cannabinoid receptors in human immune tissues and leukocyte subpopulations
• Histone Modifications Are Associated with Delta (9)-tetrahydrocannabinol-Mediated Alterations in Antigen-Specific T Cell Responses
• Immunoactive effects of cannabinoids: considerations for the therapeutic use of cannabinoid receptor agonists and antagonists
• Interaction Between The Protective Effects Of Cannabidiol And Palmitoylethanolamide In Experimental Model Of Multiple Sclerosis In C57BL/6 Mice

Infant Development

• Endocannabinoids, feeding and suckling – from our perspective
• Endocannabinoids potently protect the newborn brain against AMPA-kainate receptor-mediated excitotoxic damage
• The Endocannabinoid-CB Receptor System: Importance for development and in pediatric disease

Inflammation

• Anti-inflammatory effects of the cannabidiol derivative dimethylheptyl-cannabidiol – studies in BV-2 microglia and encephalitogenic T cells
• Anti-Inflammatory Role of Cannabidiol and O-1602 in Cerulein-Induced Acute Pancreatitis in Mice
• Cannabidiol as an Emergent Therapeutic Strategy for Lessening the Impact of Inflammation on Oxidative Stress
• Cannabidiol attenuates cardiac dysfunction, oxidative stress, fibrosis, and inflammatory and cell death signaling pathways in diabetic cardiomyopathy
• Cannabidiol exerts sebostatic and antiinflammatory effects on human sebocytes
• Cannabidiol provides long-lasting protection against the deleterious effects of inflammation in a viral model of multiple sclerosis: A role for A2A receptors
• Cannabidiol Reduces Aβ-Induced Neuroinflammation and Promotes Hippocampal Neurogenesis through PPARγ Involvement
• Cannabidiol Reduces Intestinal Inflammation through the Control of Neuroimmune Axis
• Cannabidiol reduces lipopolysaccharide-induced vascular changes and inflammation in the mouse brain: an intravital microscopy study
• CANNABINOID-BASED DRUGS AS ANTI-INFLAMMATORY THERAPEUTICS
• Cannabinoid CB2 receptors in human brain inflammation
• Cannabinoid CB2 receptors in the gastrointestinal tract: a regulatory system in states of inflammation
• Cannabinoid receptor 2 as a potential therapeutic target in rheumatoid arthritis
• Cannabinoids and the immune system: Potential for the treatment of inflammatory diseases
• Cannabinoids as novel anti-inflammatory drugs
• Cannabinoids in models of chronic inflammatory conditions
• Cannabinoids, inflammation, and fibrosis
• Cannabinoids mediate opposing effects on inflammation-induced intestinal permeability
• Cannabinoids Reduce Markers of Inflammation and Fibrosis in Pancreatic Stellate Cells
• Cannabinoids suppress inflammatory and neuropathic pain by targeting α3 glycine receptors
• Cannabinomimetic Control of Mast Cell Mediator Release: New Perspective in Chronic Inflammation
• Clinical Implications for Cannabinoid Use in the Rheumatic Diseases
• Endocannabinoids and fatty acid amides in cancer inflammation and related disorders
• Evaluation of the Cyclooxygenase Inhibiting Effects of Six Major Cannabinoids Isolated from Cannabis sativa
• Modulation of Inflammatory Responses by a Cannabinoid-2–Selective Agonist after Spinal Cord Injury
• Overcoming the Bell‐Shaped Dose‐Response of Cannabidiol by Using Cannabis Extract Enriched in Cannabidiol
• Oxyradical Stress, Endocannabinoids, and Atherosclerosis
• Role of myeloid-derived suppressor cells in amelioration of experimental autoimmune hepatitis following activation of TRPV1 receptors by cannabidiol
• Role of the Endocannabinoid System in the Neuroendocrine Responses to Inflammation
• Sex differences in anti-allodynic, anti-hyperalgesic and anti-edema effects of Δ9-tetrahydrocannabinol in the rat
• Suppression of human macrophage interleukin-6 by a nonpsychoactive cannabinoid acid
• The CB2 cannabinoid receptor-selective agonist O-3223 reduces pain and inflammation without apparent cannabinoid behavioral effects
• The effects of Δ9-tetrahydrocannabinol and cannabidiol alone and in combination on damage, inflammation and in vitro motility disturbances in rat colitis
• The endocannabinoid 2-AG protects the blood–brain barrier after closed head injury and inhibits mRNA expression of proinflammatory cytokines

Ischemia

• Activation of Cannabinoid CB2 Receptor–Mediated AMPK-CREB Pathway Reduces Cerebral Ischemic Injury
• Acute administration of cannabidiol in vivo suppresses ischaemia-induced cardiac arrhythmias and reduces infarct size when given at reperfusion
• Cannabidiol, a nonpsychoactive Cannabis constituent, protects against myocardial ischemic reperfusion injury
• Cannabidiol administration after hypoxia-ischemia to newborn rats reduces long-term brain injury and restores neurobehavioral function
• Effects of Cannabidiol and Hypothermia on Short-Term Brain Damage in New-Born Piglets after Acute Hypoxia-Ischemia
• HU­211, a Novel Noncompetitive N­Methyl­D­Aspartate Antagonist, Improves Neurological Deficit and Reduces Infarct Volume After Reversible Focal Cerebral Ischemia in the Rat
• Mechanisms of cannabidiol neuroprotection in hypoxic-ischemic newborn pigs: Role of 5HT1A and CB2 receptors
• The Cannabinoid Agonist Win55212 Reduces Brain Damage in an In Vivo Model of Hypoxic-Ischemic Encephalopathy in Newborn Rats
• The Cannabinoid WIN55212-2 Promotes Neural Repair After Neonatal Hypoxia–Ischemia
• Therapeutic potential of cannabidiol against ischemia/reperfusion liver injury in rats
• Therapeutic Potential of Non-Psychotropic Cannabidiol in Ischemic Stroke
• Update on the Role of Cannabinoid Receptors after Ischemic Stroke

Kidney

• Cannabidiol Attenuates Cisplatin-Induced Nephrotoxicity by Decreasing Oxidative/Nitrosative Stress, Inflammation, and Cell Death
• Recreational Marijuana Use is Not Associated with Worse Outcomes After Renal Transplantation

Krabbe disease

• Cannabinoids as novel anti-inflammatory drugs
• Cannabinoids inhibit neurodegeneration in models of multiple sclerosis
• CB2 cannabinoid receptors as an emerging target for demyelinating diseases: from neuroimmune interactions to cell replacement strategies
• Direct suppression of autoreactive lymphocytes in the central nervous system via the CB2 receptor
• Experimental autoimmune encephalomyelitis disrupts endocannabinoid-mediated neuroprotection
• The endocannabinoid system as a target for the treatment of neurodegenerative disease
• The Endocannabinoid System Is Dysregulated in Multiple Sclerosis and in Experimental Autoimmune Encephalomyelitis
• Therapeutic Action of Cannabinoids in a Murine Model of Multiple Sclerosis

Leukemia

• D9-Tetrahydrocannabinol-Induced Apoptosis in Jurkat Leukemia T Cells Is Regulated by Translocation of Bad to Mitochondria
• Dronabinol has preferential antileukemic activity in acute lymphoblastic and myeloid leukemia with lymphoid differentiation patterns
• Enhancing the Activity of Cannabidiol and Other Cannabinoids In Vitro Through Modifications to Drug Combinations and Treatment Schedules

Liver

• Cannabidiol improves brain and liver function in a fulminant hepatic failure-induced model of hepatic encephalopathy in mice
• Cannabidiol protects liver from binge alcohol-induced steatosis by mechanisms including inhibition of oxidative stress and increase in autophagy
• Endocannabinoids in Liver Disease
• Exogenous hepatitis B virus envelope proteins induce endoplasmic reticulum stress: involvement of cannabinoid axis in liver cancer cells
• Identification of cytochrome P450 enzymes responsible for metabolism of cannabidiol by human liver microsomes
• Protective effect of cannabidiol against cadmium hepatotoxicity in rats
• Role of myeloid-derived suppressor cells in amelioration of experimental autoimmune hepatitis following activation of TRPV1 receptors by cannabidiol

Lung Cancer

• Cannabidiol Inhibits Cancer Cell Invasion Via Upregulation Of Tissue Inhibitor Of Matrix Metalloproteinases-1
• Cannabidiol inhibits lung cancer cell invasion and metastasis via intercellular adhesion molecule-1
• Cannabinoid Receptors, CB1 and CB2, as Novel Targets for Inhibition of Non-Small Cell Lung Cancer Growth and Metastasis
• Cannabinoids for Cancer Treatment: Progress and Promise
• COX-2 and PPAR-g Confer Cannabidiol-Induced Apoptosis of Human Lung Cancer Cells
• Δ9-Tetrahydrocannabinol inhibits epithelial growth factor-induced lung cancer cell migration in vitro as well as its growth and metastasis in vivo
• Marijuana Use and the Risk of Lung and Upper Aerodigestive Tract Cancers: Results of a Population-Based Case-Control Study
• Pathways mediating the effects of cannabidiol on the reduction of breast cancer cell proliferation, invasion, and metastasis

Lupus

• Cannabinoids, inflammation, and fibrosis
• Effects of cannabinoids on LPS-stimulated inflammatory mediator release from macrophages: Involvement of eicosanoids
• Endogenous Interleukin-1 Receptor Antagonist Mediates Anti-Inflammatory and Neuroprotective Actions of Cannabinoids in Neurons and Glia
• Recent advances in cannabinoid receptor agonists and antagonists
• Suppression of human macrophage interleukin-6 by a nonpsychoactive cannabinoid acid

Lyme Disease

• Antibacterial activity of Δ9-­tetrahydrocannabinol and cannabidiol
• Antibacterial Cannabinoids from Cannabis sativa: A Structure-Activity Study
• Antimicrobial Activity of Cannabis sativa L.
• Essential oils of different cultivars of Cannabis sativa L. and their antimicrobial activity
• Extraction of cannabinoids from cannabis sativa L plant and its potential antimicrobial activity
• In vitro antibacterial activity of Cannabis sativa leaf extracts to some selective pathogenicbacterial strains

Memory

• Cannabinoid facilitation of fear extinction memory recall in humans
• Impact of cannabidiol on the acute memory and psychotomimetic effects of smoked cannabis: naturalistic study
• Keep off the grass Cannabis? Cognition and addiction
• Non-acute (residual) neurocognitive effects of cannabis Use: A meta-analytic study
• On Disruption of Fear Memory by Reconsolidation Blockade: Evidence from Cannabidiol Treatment
• The cannabinoid receptor agonist WIN 55-212-2 facilitates the extinction of contextual fear memory and spatial memory in rats
• Tolerance to the memory disruptive effects of cannabinoids involves adaptation by hippocampal neurons

Mental Illness

• Adolescent Exposure to Chronic Delta-9-Tetrahydrocannabinol Blocks Opiate Dependence in Maternally Deprived Rats
• β-Caryophyllene, a CB2 receptor agonist produces multiple behavioral changes relevant to anxiety and depression in mice
• Brain CB2 Receptors: Implications for Neuropsychiatric Disorders
• Cannabidiol, a Cannabis sativa constituent, as an antipsychotic drug
• Cannabidiol, a Nonpsychotropic Component of Cannabis, Inhibits Cue-Induced Heroin Seeking and Normalizes Discrete Mesolimbic Neuronal Disturbances
• Cannabidiol as a potential treatment for psychosis
• Cannabidiol enhances anandamide signaling and alleviates psychotic symptoms of schizophrenia
• Cannabidiol for the treatment of psychosis in Parkinson's disease
• Cannabidiol, neuroprotection and neuropsychiatric disorders
• Cannabidiol reverses MK-801-induced disruption of prepulse inhibition in mice
• Cannabidiol reverses the mCPP-induced increase in marble-burying behavior
• Cannabinoid CB1 receptors in the dorsal hippocampus and prelimbic medial prefrontal cortex modulate anxiety-like behavior in rats: Additional evidence
• Cannabinoids in bipolar affective disorder: a review and discussion of their therapeutic potential
• Cannabis as a substitute for alcohol and other drugs
• CB1 cannabinoid receptor stimulation during adolescence impairs the maturation of GABA function in the adult rat prefrontal cortex
• Distinct Neurobehavioural Effects of Cannabidiol in Transmembrane Domain Neuregulin 1 Mutant Mice
• Effects of cannabidiol on schizophrenia-like symptoms in people who use cannabis
• Effects of cannabinoid drugs on the deficit of prepulse inhibition of startle in an animal model of schizophrenia: the SHR strain
• Influence of Treatment of Tourette Syndrome with Δ9-Tetrahydrocannabinol (Δ9-THC) on Neuropsychological Performance
• Joint Effects: A Pilot Investigation of the Impact of Bipolar Disorder and Marijuana Use on Cognitive Function and Mood
• Long term marijuana users seeking medical cannabis in California (2001–2007): demographics, social characteristics, patterns of cannabis and other drug use of 4117 applicants
• Motor effects of delta 9 THC in cerebellar Lurcher mutant mice
• Multiple mechanisms involved in the large-spectrum therapeutic potential of cannabidiol in psychiatric disorders
• Neural basis of anxiolytic effects of cannabidiol (CBD) in generalized social anxiety disorder: a preliminary report - ResearchGate
• Opposite Effects of D-9-Tetrahydrocannabinol and Cannabidiol on Human Brain Function and Psychopathology
• The anxiolytic effect of cannabidiol on chronically stressed mice depends on hippocampal neurogenesis: involvement of the endocannabinoid system
• The Development of Cannabidiol as a Psychiatric Therapeutic: A Review of Its Antipsychotic Efficacy and Possible Underlying Pharmacodynamic Mechanisms
• The endocannabinoid system and emotional Processing: A pharmacological fMRI study with Δ9-tetrahydrocannabinol
• Therapeutical use of the cannabinoids in psychiatry

Migraine

• Activation of CB2 receptors as a potential therapeutic target for migraine: evaluation in an animal model
• Clinical Endocannabinoid Deficiency (CECD): Can this Concept Explain Therapeutic Benefits of Cannabis in Migraine, Fibromyalgia, Irritable Bowel Syndrome and other Treatment-Resistant Conditions
• Clinical endocannabinoid deficiency (CECD) revisited: Can this concept explain the therapeutic benefits of cannabis in migraine, fibromyalgia, irritable bowel syndrome and other treatment-resistant conditions
• Comprehensive Review of Medicinal Marijuana, Cannabinoids, and Therapeutic Implications in Medicine and Headache: What a Long Strange Trip It’s Been
• Effects of anandamide in migraine: data from an animal model
• Endocannabinoids in the Brainstem Modulate Dural Trigeminovascular Nociceptive Traffic via CB1 and “Triptan” Receptors: Implications in Migraine
• The endocannabinoid system and migraine

Mitochondria

• Cannabidiol Protects against Doxorubicin-Induced Cardiomyopathy by Modulating Mitochondrial Function and Biogenesis
• Cannabidiol Targets Mitochondria to Regulate Intracellular Ca2 Levels
• Mitochondria: a possible nexus for the regulation of energy homeostasis by the endocannabinoid system

MTHFR Gene Mutation

• Anti-inflammatory effects of the cannabidiol derivative dimethylheptyl-cannabidiol – studies in BV-2 microglia and encephalitogenic T cells
• Cannabidiol affects the expression of genes involved in zinc homeostasis in BV-2 microglial cells
• Cannabidiol Post-Treatment Alleviates Rat Epileptic-Related Behaviors and Activates Hippocampal Cell Autophagy Pathway Along with Antioxidant Defense in Chronic Phase of Pilocarpine-Induced Seizure
• Cannabidiol Protects against Doxorubicin-Induced Cardiomyopathy by Modulating Mitochondrial Function and Biogenesis
• Mechanisms of cannabidiol neuroprotection in hypoxic-ischemic newborn pigs: Role of 5HT1A and CB2 receptors
• Protective effect of cannabidiol against cadmium hepatotoxicity in rats
• Therapeutic potential of cannabidiol against ischemia/reperfusion liver injury in rats

Multiple Sclerosis

• A randomized, double-blind, placebo-controlled, parallel-group, enriched-design study of nabiximols* (Sativex®), as add-on therapy, in subjects with refractory spasticity caused by multiple sclerosis
• Cannabidiol provides long-lasting protection against the deleterious effects of inflammation in a viral model of multiple sclerosis: A role for A2A receptors
• Cannabinoid Modulation of Neuroinflammatory Disorders
• Cannabinoids and multiple sclerosis
• Cannabinoids control spasticity and tremor in a multiple sclerosis model
• Cannabinoids for treatment of spasticity and other symptoms related to multiple sclerosis (CAMS study): multicentre randomised placebo-controlled trial
• Cannabinoids in multiple sclerosis (CAMS) study: safety and efficacy data for 12 months follow up
• Cannabinoids in the management of spasticity associated with multiple sclerosis
• Cannabinoids inhibit neurodegeneration in models of multiple sclerosis
• Clinical experiences with cannabinoids in spasticity management in multiple sclerosis
• Effects of cannabis on cognitive function in patients with multiple sclerosis
• Efficacy, safety and tolerability of an orally administered cannabis extract in the treatment of spasticity in patients with multiple sclerosis: a randomized, double-blind, placebo-controlled, crossover study
• Interaction Between The Protective Effects Of Cannabidiol And Palmitoylethanolamide In Experimental Model Of Multiple Sclerosis In C57BL/6 Mice
• Psychopathological and cognitive effects of therapeutic cannabinoids in multiple sclerosis: a double-blind, placebo controlled, crossover study
• Randomized, controlled trial of cannabis-based medicine in central pain in multiple sclerosis
• Sativex in the Management of Multiple Sclerosis-Related Spasticity: Role of the Corticospinal Modulation
• Smoked cannabis for spasticity in multiple sclerosis: a randomized, placebo-controlled trial
• Symptomatic therapy in multiple sclerosis: the role of cannabinoids in treating spasticity
• THC:CBD Observational Study Data: Evolution of Resistant MS Spasticity and Associated Symptoms
• The cannabinoids: An overview. Therapeutic implications in vomiting and nausea after cancer chemotherapy, in appetite promotion, in multiple sclerosis and in neuroprotection
• The effect of cannabis on tremor in patients with multiple sclerosis
• The Endocannabinoid System Is Dysregulated in Multiple Sclerosis and in Experimental Autoimmune Encephalomyelitis
• Therapeutic Action of Cannabinoids in a Murine Model of Multiple Sclerosis
• Whole plant cannabis extracts in the treatment of spasticity in multiple sclerosis: a systematic review

National Institute on Drug Abuse (NIDA)

• NIDA Research on the Therapeutic Benefits of Cannabis and Cannabinoids

Nausea

• Cannabidiol, a non-psychotropic component of cannabis, attenuates vomiting and nausea-like behaviour via indirect agonism of 5-HT1A somatodendritic autoreceptors in the dorsal raphe nucleus
• Cannabidiolic acid prevents vomiting in Suncus murinus and nausea-induced behaviour in rats by enhancing 5-HT1A receptor activation
• Cannabinoid Regulation of Acute and Anticipatory Nausea
• Interaction between non-psychotropic cannabinoids in marihuana: effect of cannabigerol (CBG) on the anti-nausea or anti-emetic effects of cannabidiol (CBD) in rats and shrews
• Regulation of nausea and vomiting by cannabinoids
• The cannabinoids: An overview. Therapeutic implications in vomiting and nausea after cancer chemotherapy, in appetite promotion, in multiple sclerosis and in neuroprotection

Nervous System

• Cannabinoid–Dopamine Interaction in the Pathophysiology and Treatment of CNS Disorders
• Cannabinoid receptors 1 and 2 (CB1 and CB2), their distribution, ligands and functional involvement in nervous system structures — A short review
• Direct suppression of autoreactive lymphocytes in the central nervous system via the CB2 receptor
• Expression of central and peripheral cannabinoid receptors in human immune tissues and leukocyte subpopulations
• Phytocannabinoids as novel therapeutic agents in CNS disorders
• The effect of cannabichromene on adult neural stem-progenitor cells
• Therapeutic Potential of Cannabinoids in CNS Disease

Neuro-protective and Neuro-generative

• Activation of Type 1 Cannabinoid Receptor (CB1R) Promotes Neurogenesis in Murine Subventricular Zone Cell Cultures
• An endogenous cannabinoid (2-AG) is neuroprotective after brain injury
• Cannabidiol administration after hypoxia-ischemia to newborn rats reduces long-term brain injury and restores neurobehavioral function
• Cannabidiol and (−)Δ9-tetrahydrocannabinol are neuroprotective antioxidants
• Cannabidiol for neurodegenerative disorders: important new clinical applications for this phytocannabinoid
• Cannabidiol inhibits pathogenic T cells, decreases spinal microglial activation and ameliorates multiple sclerosis-like disease in C57BL/6 mice
• Cannabidiol, neuroprotection and neuropsychiatric disorders
• Cannabidiol Reduces Aβ-Induced Neuroinflammation and Promotes Hippocampal Neurogenesis through PPARγ Involvement
• Cannabinoid CB2 receptor: a new target for controlling neural cell survival
• Cannabinoid receptor CB1 mediates baseline and activity-induced survival of new neurons in adult hippocampal neurogenesis
• Cannabinoids and Neuroprotection in Basal Ganglia Disorders
• Cannabinoids in Neurodegenerative Disorders and Stroke/Brain Trauma: From Preclinical Models to Clinical Applications
• Cannabinoids inhibit neurodegeneration in models of multiple sclerosis
• Cannabinoids promote embryonic and adult hippocampus neurogenesis and produce anxiolytic- and antidepressant-like effects
• Cannabinoids: Well-Suited Candidates for the Treatment of Perinatal Brain Injury
• CB1 and CB2 Cannabinoid Receptor Antagonists Prevent Minocycline-Induced Neuroprotection Following Traumatic Brain Injury in Mice
• CB1 Cannabinoid Receptors and On-Demand Defense Against Excitotoxicity
• Comparison of Cannabidiol, Antioxidants, and Diuretics in Reversing Binge Ethanol-Induced Neurotoxicity
• Δ9-Tetrahydrocannabinol Prevents Methamphetamine-Induced Neurotoxicity
• Endocannabinoid Signaling In Neurotoxicity And Neuroprotection
• Endocannabinoids and traumatic brain injury
• Experimental autoimmune encephalomyelitis disrupts endocannabinoid-mediated neuroprotection
• Long-­term behavioral and biochemical effects of an ultra-­low dose of Δ9-­tetrahydrocannabinol (THC): neuroprotection and ERK signaling
• Molecular mechanisms of cannabinoid protection from neuronal excitotoxicity
• Neuroprotective and Blood-Retinal Barrier-Preserving Effects of Cannabidiol in Experimental Diabetes
• Neuroprotective Effect of(−)Δ9-Tetrahydrocannabinol and Cannabidiol in N-Methyl-d-Aspartate-Induced Retinal Neurotoxicity
• Neuroprotection by Δ9-Tetrahydrocannabinol, the Main Active Compound in Marijuana, against Ouabain-Induced In Vivo Excitotoxicity
• Neuroprotective antioxidants from marijuana
• Neuroprotective effect of cannabidiol, a non-psychoactive component from Cannabis sativa, on beta-amyloid-induced toxicity in PC12 cells
• Nonpsychoactive Cannabidiol Prevents Prion Accumulation and Protects Neurons against Prion Toxicity
• Preclinical evaluation of SMM-189, a cannabinoid receptor 2-specific inverse agonist
• Prospects for cannabinoid therapies in basal ganglia disorders
• Protective effects of Δ9-tetrahydrocannabinol against N-methyl-D-aspartate-induced AF5 cell death
• The Cannabinoid WIN55212-2 Promotes Neural Repair After Neonatal Hypoxia–Ischemia
• The cannabinoids: An overview. Therapeutic implications in vomiting and nausea after cancer chemotherapy, in appetite promotion, in multiple sclerosis and in neuroprotection
• The CB1 cannabinoid receptor signals striatal neuroprotection via a PI3K Akt mTORC1 BDNF pathway
• The endocannabinoid 2-AG protects the blood–brain barrier after closed head injury and inhibits mRNA expression of proinflammatory cytokines
• The endocannabinoid system as a target for the treatment of neurodegenerative disease
• The endocannabinoid system in normal and pathological brain ageing
• The neuroprotective role of endocannabinoids against chemical-induced injury and other adverse effects
• United States patent on cannabinoids as antioxidants and neuroprotectants

Neuropathy

• An Exploratory Human Laboratory Experiment Evaluating Vaporized Cannabis in the Treatment of Neuropathic Pain from Spinal Cord Injury and Disease
• Cannabidiol inhibits paclitaxel-induced neuropathic pain through 5-HT1A receptors without diminishing nervous system function or chemotherapy efficacy
• Cannabinoids delivery systems based on supramolecular inclusion complexes and polymeric nanocapsules for treatment of neuropathic pain
• Cannabinoids for Neuropathic Pain
• Cannabinoids suppress inflammatory and neuropathic pain by targeting α3 glycine receptors
• Smoked cannabis for chronic neuropathic pain: a randomized controlled trial

Non-Hodgkin's Lymphoma

• Expression of cannabinoid receptors type 1 and type 2 in non-Hodgkin lymphoma: Growth inhibition by receptor activation

Nutrition

• An Increase in the Omega-6-Omega-3 Fatty Acid Ratio Increases the Risk for Obesity
• Nutritional omega-3 deficiency abolishes endocannabinoid-mediated neuronal functions
• The Composition of Hemp Seed Oil and Its Potential as an Important Source of Nutrition

Obesity

• An Increase in the Omega-6-Omega-3 Fatty Acid Ratio Increases the Risk for Obesity
• Cannabinoid receptor 2 as anti-obesity target: inflammation, fat storage and browning modulation
• Pathophysiological role of host microbiota in the development of obesity
• The cannabinoid Δ9-tetrahydrocannabivarin (THCV) ameliorates insulin sensitivity in two mouse models of obesity
• The endocannabinoid system in obesity and type 2 diabetes

Obsessive Compulsive Disorder (OCD)

• Cannabidiol reverses the mCPP-induced increase in marble-burying behavior
• Facilitation of CB1 receptor-mediated neurotransmission decreases marble burying

Optic Function

• Cannabinoid Receptors CB1 and CB2 Modulate the Electroretinographic Waves in Vervet Monkeys

Organ Transplants

• Marijuana Use in Potential Liver Transplant Candidates

Pain

• Amygdala activity contributes to the dissociative effect of cannabis on pain perception
• An Exploratory Human Laboratory Experiment Evaluating Vaporized Cannabis in the Treatment of Neuropathic Pain from Spinal Cord Injury and Disease
• Assessing efficacy of non-opioid analgesics in experimental pain models in healthy volunteers- an updated review
• Cannabidiol inhibits paclitaxel-induced neuropathic pain through 5-HT1A receptors without diminishing nervous system function or chemotherapy efficacy
• Cannabinoid CB2 Receptors Regulate Central Sensitization and Pain Responses Associated with Osteoarthritis of the Knee Joint
• Cannabinoid–Opioid Interaction in Chronic Pain
• Cannabinoid receptors and pain
• Cannabinoids delivery systems based on supramolecular inclusion complexes and polymeric nanocapsules for treatment of neuropathic pain
• Cannabinoids for Neuropathic Pain
• Cannabinoids for treatment of chronic non-cancer pain; a systematic review of randomized trials
• Cannabinoids in the management of difficult to treat pain
• Cannabinoids suppress inflammatory and neuropathic pain by targeting α3 glycine receptors
• Cannabinoids with children
• Cannabis for the Management of Pain: Assessment of Safety Study (COMPASS)
• Clinical Implications for Cannabinoid Use in the Rheumatic Diseases
• Combined treatment with morphine and Δ9-tetrahydrocannibinol (THC) in rhesus monkeys: antinociceptive tolerance and withdrawal
• δ-Ctenitoxin-Pn1a, a Peptide from Phoneutria nigriventer Spider Venom, Shows Antinociceptive Effect Involving Opioid and Cannabinoid Systems, in Rats
• Hyperalgesia by low doses of the local anesthetic lidocaine involves cannabinoid signaling: An fMRI study in mice
• Injury, Pain, and Prescription Opioid Use Among Former National Football League (NFL) Players
• Overcoming the Bell‐Shaped Dose‐Response of Cannabidiol by Using Cannabis Extract Enriched in Cannabidiol
• Prescribing cannabis for harm reduction
• Role of Cannabinoids in Pain Management
• Role of the Cannabinoid System in Pain Control and Therapeutic Implications for the Management of Acute and Chronic Pain Episodes
• Sex differences in anti-allodynic, anti-hyperalgesic and anti-edema effects of Δ9-tetrahydrocannabinol in the rat
• Smoked cannabis for chronic neuropathic pain: a randomized controlled trial
• Stable dose cannabinoid medicine GW
• Survey Results of Pain Treatments in Adults with Cerebral Palsy
• Synergistic affective analgesic interaction between delta-9-tetrahydrocannabinol and morphine
• Targeting CB2 receptors and the endocannabinoid system for the treatment of pain
• The CB2 cannabinoid receptor-selective agonist O-3223 reduces pain and inflammation without apparent cannabinoid behavioral effects
• The Endocannabinoid System, Cannabinoids, and Pain
• The endogenous cannabinoid system and its role in nociceptive behavior
• The Pharmacologic and Clinical Effects of Medical Cannabis
• Therapeutic Benefits of Cannabis: A Patient Survey
• Use of prescription pain medications among medical cannabis patients: comparisons of pain levels, functioning, and patterns of alcohol and other drug use

Pancreatitis

• Anti-Inflammatory Role of Cannabidiol and O-1602 in Cerulein-Induced Acute Pancreatitis in Mice
• Cannabinoids Ameliorate Pain and Reduce Disease Pathology in Cerulein-Induced Acute Pancreatitis
• Cannabinoids Reduce Markers of Inflammation and Fibrosis in Pancreatic Stellate Cells

Parkinson's

• Cannabidiol can improve complex sleep-related behaviours associated with rapid eye movement sleep behaviour disorder in Parkinson's disease patients: a case series
• Cannabidiol for the treatment of psychosis in Parkinson's disease
• Effects of cannabidiol in the treatment of patients with Parkinson’s disease: An exploratory double-blind trial
• Promising cannabinoid-based therapies for Parkinson’s disease: motor symptoms to neuroprotection
• Self-Reported Efficacy of Cannabis and Other Complementary Medicine Modalities by Parkinson's Disease Patients in Colorado
• Survey on Cannabis Use in Parkinson’s Disease: Subjective Improvement of Motor Symptoms
• The CB1 cannabinoid receptor agonist reduces L-DOPA-induced motor fluctuation and ERK1-2 phosphorylation in 6-OHDA-lesioned rats
• The influence of cannabinoids on generic traits of neurodegeneration

Patents

• FORMULATION AND METHOD FOR INCREASING ORAL BIOAVAILABILITY OF DRUGS
• United States patent application publication for phytocannabinoids in the treatment of cancer
• United States patent on cannabinoids as antioxidants and neuroprotectants

Pets

• Identification of an endogenous 2-monoglyceride, present in canine gut, that binds to cannabinoid receptors

Pharmacokinetics

• Cannabis in the Arm: What Can we Learn from Intravenous Cannabinoid Studies
• Dietary fats and pharmaceutical lipid excipients increase systemic exposure to orally administered cannabis and cannabis-based medicines
• FORMULATION AND METHOD FOR INCREASING ORAL BIOAVAILABILITY OF DRUGS
• Human Cannabinoid Pharmacokinetics
• Pharmacokinetics and metabolism of the plant cannabinoids, delta9-tetrahydrocannabinol, cannabidiol and cannabinol

Post Traumatic Stress Disorder (PTSD)

• Association of the Cannabinoid Receptor Gene (CNR1) With ADHD and Post-Traumatic Stress Disorder
• Cannabinoids Prevent the Effects of a Footshock Followed by Situational Reminders on Emotional Processing
• Changes of endocannabinoid plasma levels following type I trauma: A prospective pilot study
• Elevated Brain Cannabinoid CB1 Receptor Availability in Posttraumatic Stress Disorder- A Positron Emission Tomography Study
• Endocannabinoid concentrations in hair are associated with PTSD symptom severity
• On Disruption of Fear Memory by Reconsolidation Blockade: Evidence from Cannabidiol Treatment
• Preliminary, open-­label, pilot study of add-­on oral Δ9-­tetrahydrocannabinol in chronic post-­traumatic stress disorder
• PTSD Symptom Reports of Patients Evaluated for the New Mexico Medical Cannabis Program

Potential of whole plant vs. single compound model

• A tale of two cannabinoids: The therapeutic rationale for combining tetrahydrocannabinol and cannabidiol
• Activity of cannabis in relation to its delta'-trans-tetrahydro-cannabinol content
• An entourage effect: inactive endogenous fatty acid glycerol esters enhance 2-arachidonoyl-glycerol cannabinoid activity
• Cannabidiol Enhances the Inhibitory Effects of Δ9-Tetrahydrocannabinol on Human Glioblastoma Cell Proliferation and Survival
• Cannabis and Cannabis Extracts: Greater Than the Sum of Their Parts
• Overcoming the Bell‐Shaped Dose‐Response of Cannabidiol by Using Cannabis Extract Enriched in Cannabidiol
• Taming THC: potential cannabis synergy and phytocannabinoid-terpenoid entourage effects

Pregnancy

• A Longitudinal Study of Prenatal Marijuana Use
• Cannabidiol changes P-gp and BCRP expression in trophoblast cell lines
• Endocannabinoid System in First Trimester Placenta: Low FAAH and High CB1 Expression Characterize Spontaneous Miscarriage
• Fetal Alcohol Spectrum Disorder: Potential Role of Endocannabinoids Signaling
• Five-year follow-up of rural Jamaican children whose mothers used marijuana during pregnancy
• Identifying Prenatal Cannabis Exposure and Effects of Concurrent Tobacco Exposure on Neonatal Growth
• Lasting impacts of prenatal cannabis exposure and the role of endogenous cannabinoids in the developing brain
• Ligand-receptor signaling with endocannabinoids in preimplantation embryo development and implantation
• Multiple Roles for the Endocannabinoid System During the Earliest Stages of Life: Pre- and Postnatal Development
• Prenatal Marijuana Exposure and Neonatal Outcomes in Jamaica: An Ethnographic Study
• The Endocannabinoid-CB Receptor System: Importance for development and in pediatric disease

Prostate Cancer

• Cannabinoid Receptor Agonist-induced Apoptosis of Human Prostate Cancer Cells LNCaP Proceeds through Sustained Activation of ERK12 Leading to G1 Cell Cycle Arrest
• Cannabinoid receptor as a novel target for the treatment of prostate cancer
• Cannabinoid receptor-dependent and -independent anti-proliferative effects of omega-3 ethanolamides in androgen receptor-positive and -negative prostate cancer cell lines
• Inhibition of human tumour prostate PC-3 cell growth by cannabinoids R( þ )-Methanandamide and JWH-015: Involvement of CB2
• Non-THC cannabinoids inhibit prostate carcinoma growth in vitro and in vivo: pro-apoptotic effects and underlying mechanisms
• Proapoptotic effect of endocannabinoids in prostate cancer cells
• The role of cannabinoids in prostate cancer: Basic science perspective and potential clinical applications

Psoriasis

• Cannabinoids inhibit human keratinocyte proliferation through a non-CB1-CB2 mechanism and have a potential therapeutic value in the treatment of psoriasis

Pulmonary Function

• Association Between Marijuana Exposure and Pulmonary Function Over 20 Years
• BRONCHODILATOR EFFECT OF Δ1-TETRAHYDROCANNABINOL
• Cannabinoid effects on ventilation and breathlessness: a pilot study of efficacy and safety
• Does smoking marijuana increase the risk of chronic obstructive pulmonary disease
• Effects of Marijuana Smoking on the Lung
• Evaluation of Serum Cytokines Levels and the Role of Cannabidiol Treatment in Animal Model of Asthma
• Inhibition of guinea-pig and human sensory nerve activity and the cough reflex in guinea-pigs by cannabinoid (CB2) receptor activation
• Marijuana and chronic obstructive lung disease: a population-based study
• Monoacylglycerol Lipase (MAGL) Inhibition Attenuates Acute Lung Injury in Mice
• Preclinical Assessment of Novel Therapeutics on the Cough Reflex: Cannabinoid Agonists as Potential Antitussives
• The effects of marijuana exposure on expiratory airflow. A study of adults who participated in the U.S. National Health and Nutrition Examination Study

Schizophrenia

• A clinical comparison of schizophrenia with and without pre-onset cannabis use disorder: a retrospective cohort study using categorical and dimensional approaches
• Cannabidiol enhances anandamide signaling and alleviates psychotic symptoms of schizophrenia
• Cannabidiol reverses MK-801-induced disruption of prepulse inhibition in mice
• Effects of cannabidiol on schizophrenia-like symptoms in people who use cannabis
• Effects of cannabinoid drugs on the deficit of prepulse inhibition of startle in an animal model of schizophrenia: the SHR strain

Sickle-cell Disease

• Cannabis use in sickle cell disease: a questionnaire study
• Pain-related behaviors and neurochemical alterations in mice expressing sickle hemoglobin: modulation by cannabinoids

Skeletal System

• Activation of Cannabinoid Receptor 2 Enhances Osteogenic Differentiation of Bone Marrow Derived Mesenchymal Stem Cells
• Cannabinoid receptors and the regulation of bone mass
• Cannabinoids and bone: endocannabinoids modulate human osteoclast function in vitro
• Cannabinoids and the skeleton: From marijuana to reversal of bone loss
• Effects of deleting cannabinoid receptor-2 on mechanical and material properties of cortical and trabecular bone
• Peripheral cannabinoid receptor, CB2, regulates bone mass
• Protective Effects of Cannabidiol on Lesion-Induced Intervertebral Disc Degeneration
• Role of cannabinoids in the regulation of bone remodeling
• The cannabinoid CB1 receptor regulates bone formation by modulating adrenergic signaling
• THE ROLE OF TYPE 2 CANNABINOID RECEPTOR IN BONE METABOLISM

Skin

• Cannabidiol exerts sebostatic and antiinflammatory effects on human sebocytes
• The endocannabinoid system of the skin in health and disease: novel perspectives and therapeutic opportunities

Sleep

• A Longitudinal Study of Prenatal Marijuana Use
• A Pilot Study into the Effects of the CB1 Cannabinoid Receptor Agonist WIN55,212-2 or the Antagonist-Inverse Agonist AM251 on Sleep in Rats
• Administration of URB597, Oleoylethanolamide or Palmitoylethanolamide Increases Waking and Dopamine in Rats
• Around‐the‐Clock Oral THC Effects on Sleep in Male Chronic Daily Cannabis Smokers
• Arousal-enhancing properties of the CB1 cannabinoid receptor antagonist SR 141716A in rats as assessed by electroencephalographic spectral and sleep-waking cycle analysis
• D9 THC as an hypnotic
• Effect of cannabis and certain of its constituents on pentobarbitone sleeping time and phenazone metabolism
• Effect of Δ-9-Tetrahydrocannabinol and Cannabidiol on Nocturnal Sleep and Early-Morning Behavior in Young Adults
• Effect of illicit recreational drugs upon sleep: Cocaine, ecstasy and marijuana
• Endocannabinoid Signaling Regulates Sleep Stability
• Functional role for cannabinoids in respiratory stability during sleep
• Intrahippocampal administration of anandamide increases REM sleep
• Intranodose ganglion injections of dronabinol attenuate serotonin-induced apnea in Sprague-Dawley rat
• Modulation of Sleep-Wake Cycles in Mice and Rats with Cannabinoids
• Potential Effects of Cannabidiol as a Wake-Promoting Agent
• Proof of concept trial of dronabinol in obstructive sleep apnea
• The effects of cannabinoid administration on sleep: a systematic review of human studies
• The Emerging Role of the Endocannabinoid System in the Sleep-Wake Cycle Modulation
• The Nonpsychoactive Cannabis Constituent Cannabidiol Is a Wake-Inducing Agent

Spasticity

• A randomized, double-blind, placebo-controlled, parallel-group, enriched-design study of nabiximols* (Sativex®), as add-on therapy, in subjects with refractory spasticity caused by multiple sclerosis
• Cannabinoids for treatment of spasticity and other symptoms related to multiple sclerosis (CAMS study): multicentre randomised placebo-controlled trial
• Cannabinoids in the management of spasticity associated with multiple sclerosis
• Cannabinoids with children
• Clinical experiences with cannabinoids in spasticity management in multiple sclerosis
• Efficacy, safety and tolerability of an orally administered cannabis extract in the treatment of spasticity in patients with multiple sclerosis: a randomized, double-blind, placebo-controlled, crossover study
• Sativex in the Management of Multiple Sclerosis-Related Spasticity: Role of the Corticospinal Modulation
• Smoked cannabis for spasticity in multiple sclerosis: a randomized, placebo-controlled trial
• Symptomatic therapy in multiple sclerosis: the role of cannabinoids in treating spasticity
• Whole plant cannabis extracts in the treatment of spasticity in multiple sclerosis: a systematic review

Sports

• Activation of Cannabinoid CB2 Receptor–Mediated AMPK-CREB Pathway Reduces Cerebral Ischemic Injury
• Activation of cortical type 2 cannabinoid receptors ameliorates ischemic brain injury
• Acute administration of cannabidiol in vivo suppresses ischaemia-induced cardiac arrhythmias and reduces infarct size when given at reperfusion
• Acute upregulation of neuronal mitochondrial type-1 cannabinoid receptor and it’s role in metabolic defects and neuronal apoptosis after TBI
• An endogenous cannabinoid (2-AG) is neuroprotective after brain injury
• Cannabidiol-treated rats exhibited higher motor score after cryogenic spinal cord injury
• Cannabidiol, a nonpsychoactive Cannabis constituent, protects against myocardial ischemic reperfusion injury
• Cannabidiol administration after hypoxia-ischemia to newborn rats reduces long-term brain injury and restores neurobehavioral function
• Cannabinoid agonist rescues learning and memory after a traumatic brain injury
• Cannabinoid CB2 Receptor Activation Attenuates Motor and Autonomic Function Deficits in a Mouse Model of Spinal Cord Injury
• Cannabinoid receptors and the regulation of bone mass
• Cannabinoids and the skeleton: From marijuana to reversal of bone loss
• Cannabis Responsive Head Injury Induced Mutiple Disabilities: A Case Report
• CB1 and CB2 Cannabinoid Receptor Antagonists Prevent Minocycline-Induced Neuroprotection Following Traumatic Brain Injury in Mice
• Early increase of cannabinoid receptor density after experimental traumatic brain injury in the newborn piglet
• Effects of Cannabidiol and Hypothermia on Short-Term Brain Damage in New-Born Piglets after Acute Hypoxia-Ischemia
• Endocannabinoids and traumatic brain injury
• Estradiol Decreases Cortical Reactive Astrogliosis after Brain Injury by a Mechanism Involving Cannabinoid Receptors
• HU­211, a Novel Noncompetitive N­Methyl­D­Aspartate Antagonist, Improves Neurological Deficit and Reduces Infarct Volume After Reversible Focal Cerebral Ischemia in the Rat
• Injury, Pain, and Prescription Opioid Use Among Former National Football League (NFL) Players
• Mechanisms of cannabidiol neuroprotection in hypoxic-ischemic newborn pigs: Role of 5HT1A and CB2 receptors
• Peripheral cannabinoid receptor, CB2, regulates bone mass
• Role of cannabinoids in the regulation of bone remodeling
• The Cannabinoid Agonist Win55212 Reduces Brain Damage in an In Vivo Model of Hypoxic-Ischemic Encephalopathy in Newborn Rats
• The cannabinoid CB1 receptor regulates bone formation by modulating adrenergic signaling
• The endocannabinoid 2-AG protects the blood–brain barrier after closed head injury and inhibits mRNA expression of proinflammatory cytokines
• THE ROLE OF TYPE 2 CANNABINOID RECEPTOR IN BONE METABOLISM
• Therapeutic potential of cannabidiol against ischemia/reperfusion liver injury in rats
• Therapeutic Potential of Non-Psychotropic Cannabidiol in Ischemic Stroke
• Tissue Engineering of Cartilage; Can Cannabinoids Help?
• Update on the Role of Cannabinoid Receptors after Ischemic Stroke

Stroke

• Cannabinoids in experimental stroke: a systematic review and meta-analysis
• Therapeutic Potential of Non-Psychotropic Cannabidiol in Ischemic Stroke
• Update on the Role of Cannabinoid Receptors after Ischemic Stroke

Thyroid

• Evidence for functional CB1 cannabinoid receptor expressed in the rat thyroid

Tourette's syndrome

• Cannabinoids for Tourette’s Syndrome (Review)
• Cannabinoids: possible role in patho-physiology and therapy of Gilles de la Tourette syndrome
• Influence of Treatment of Tourette Syndrome with Δ9-Tetrahydrocannabinol (Δ9-THC) on Neuropsychological Performance
• Treatment of Tourette syndrome with cannabinoids
• Treatment of Tourette-Syndrome with Δ9-Tetrahydrocannabinol (THC): a randomized crossover trial

Traumatic Brain Injury (TBI)

• Acute upregulation of neuronal mitochondrial type-1 cannabinoid receptor and it’s role in metabolic defects and neuronal apoptosis after TBI
• An endogenous cannabinoid (2-AG) is neuroprotective after brain injury
• Cannabinoid agonist rescues learning and memory after a traumatic brain injury
• CB1 and CB2 Cannabinoid Receptor Antagonists Prevent Minocycline-Induced Neuroprotection Following Traumatic Brain Injury in Mice
• Early increase of cannabinoid receptor density after experimental traumatic brain injury in the newborn piglet
• Effect of Marijuana Use on Outcomes in Traumatic Brain Injury
• Endocannabinoids: A Promising Impact for Traumatic Brain Injury
• Endocannabinoids and traumatic brain injury
• Estradiol Decreases Cortical Reactive Astrogliosis after Brain Injury by a Mechanism Involving Cannabinoid Receptors
• Preclinical evaluation of SMM-189, a cannabinoid receptor 2-specific inverse agonist
• The endocannabinoid 2-AG protects the blood–brain barrier after closed head injury and inhibits mRNA expression of proinflammatory cytokines