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This site contains copyrighted material the use of which has not always been specifically authorized by the copyright owner. We are making such material available in our efforts to advance understanding of issues of significance. We believe this constitutes a 'fair use' of any such copyrighted material as provided for in section 107 of the US Copyright Law. In accordance with Title 17 U.S.C. Section 107, the material on this site is distributed without profit to those who have expressed a prior interest in receiving the included information for research and educational purposes.

Addiction
Alzheimer's Dementia
Amyotrophic Lateral Sclerosis (ALS) (Lou Gehrig's)
Antibacterial
Antioxidant
Antiprion
Anxiety
Appetite
Arthritis
Asthma
Attention Deficit Hyperactivity Disorder (ADHD)
Autism
Autoimmune
Batten Disease
Breast Cancer
Cancer
Cannabidiol (CBD)
Cardiovascular
CB1 Receptor
CB2 Receptor
CBDV
Cellular Function
Cerebral Palsy
Cognition
Colon Cancer
Crohn's Disease
D9-Tetrahydrocannabinol (THC)
D9-Tetrahydrocannabinolic acid (THCA)
Depression
Diabetes
Drug Interactions
Edema
Emesis
Endocannabinoid System (ECS)
Endocrine System
Epilepsy
Fibromyalgia
Fibrosis
Gastrointestinal Disease
General

Glaucoma
Glioblastoma
Glioma
HIV
Huntington's Disease
Immune Function
Infant Development
Inflammation
Ischemia
Kidney
Krabbe disease
Leukemia
Liver
Lung Cancer
Lupus
Lyme Disease
Memory
Mental Illness
Migraine
Mitochondria
MTHFR Gene Mutation
Multiple Sclerosis
Nausea
Nervous System
Neuro-protective and Neuro-generative
Neuropathy
Non-Hodgkin's Lymphoma
Nutrition
Obesity
Obsessive Compulsive Disorder (OCD)
Optic Function
Organ Transplants
Pain
Pancreatitis
Parkinson's
Patents
Pets
Pharmacokinetics
Post Traumatic Stress Disorder (PTSD)
Potential of whole plant vs. single compound model

Pregnancy
Prostate Cancer
Psoriasis
Pulmonary Function
Safety
Schizophrenia
Sickle-cell Disease
Skeletal System
Skin
Sleep
Spasticity
Sports
Stroke
Tourette's syndrome
Traumatic Brain Injury (TBI)

Addiction

Adolescent Exposure to Chronic Delta-9-Tetrahydrocannabinol Blocks Opiate Dependence in Maternally Deprived Rats
Cannabidiol, a Nonpsychotropic Component of Cannabis, Inhibits Cue-Induced Heroin Seeking and Normalizes Discrete Mesolimbic Neuronal Disturbances
Cannabidiol as an Intervention for Addictive Behaviors- A Systematic Review of the Evidence
Cannabis as a substitute for alcohol and other drugs
Interactions between delta9-tetrahydrocannabinol and heroin- self-administration in rhesus monkeys
Involvement of the endocannabinoid system in drug addiction
Medical Cannabis Laws and Opioid Analgesic Overdose Mortality in the United States, 1999-2010

Alzheimer's Dementia

Amyloid-beta inhibits E-S Potentiation through suppression of cannabinoid receptor 1 dependent synaptic disinhibition
A Molecular Link Between the Active Component of Marijuana and Alzheimer's Disease Pathology
Cannabinoids for treatment of Alzheimer’s disease- moving toward the clinic
Cannabidiol and other cannabinoids reduce microglial activation in vitro and in vivo_ relevance to Alzheimer's disease
Cannabinoids for the treatment of dementia
Cannabinoids and Dementia- A Review of Clinical and Preclinical Data
Delta-9-tetrahydrocannabinol for nighttime agitation in severe dementia
Natural Phytochemicals in the Treatment and Prevention of Dementia- An Overview
The influence of cannabinoids on generic traits of neurodegeneration
The role of endocannabinoid signaling in the molecular mechanisms of neurodegeneration in Alzheimer's disease

Amyotrophic Lateral Sclerosis (ALS) (Lou Gehrig's)

Amyotrophic lateral sclerosis- delayed disease progression in mice by treatment with a cannabinoid
Cannabinol delays symptom onset in SOD1 (G93A) transgenic mice without affecting survival
Cannabis and Amyotrophic Lateral Sclerosis- Hypothetical and Practical Applications, and a Call for Clinical Trials

Antibacterial

Antimicrobial Activity of Cannabis sativa L.
Antibacterial activity of D9_tetrahydrocannabinol and cannabidiol
Antibacterial Cannabinoids from Cannabis sativa- A Structure-Activity Study
Essential oils of different cultivars of Cannabis sativa L. and their antimicrobial activity
Extraction of cannabinoids from cannabis sativa L plant and its potential antimicrobial activity
In vitro antibacterial activity of Cannabis sativa leaf extracts to some selective pathogenicbacterial strains
Marijuana, Tetrahydrocannabinol, and Pulmonary Antibacterial Defenses

Antioxidant

Cannabidiol Post-Treatment Alleviates Rat Epileptic-Related Behaviors and Activates Hippocampal Cell Autophagy Pathway Along with Antioxidant Defense in Chronic Phase of Pilocarpine-Induced Seizure
Cannabidiol protects liver from binge alcohol-induced steatosis by mechanisms including inhibition of oxidative stress and increase in autophagy
Cannabidiol as an Emergent Therapeutic Strategy for Lessening the Impact of Inflammation on Oxidative Stress
Cannabidiol and (−)Δ9-tetrahydrocannabinol are neuroprotective antioxidants
Oxyradical Stress, Endocannabinoids, and Atherosclerosis
Prospects for cannabinoid therapies in basal ganglia disorders
Protective effects of Δ9-tetrahydrocannabinol against N-methyl-D-aspartate-induced AF5 cell death
Mechanism for inhibitory effect of cannabidiol on microsomal testosterone oxidation in male rat liver
Neuroprotective antioxidants from marijuana

Antiprion

Nonpsychoactive Cannabidiol Prevents Prion Accumulation and Protects Neurons against Prion Toxicity

Anxiety

Action of Cannabidiol on the Anxiety and Other Effects Produced by D9-THC in Normal Subjects
Antidepressant-Like and Anxiolytic-Like Effects of Cannabidiol- A Chemical Compound of Cannabis sativa
Cannabidiol, a Cannabis sativa constituent, as an anxiolytic drug
Chronic blockade of cannabinoid CB2 receptors induces anxiolytic-like actions associated with alterations in GABA(A) receptors
Cannabinoid-related agents in the treatment of anxiety disorders- current knowledge and future perspectives
Distinct Effects of9-Tetrahydrocannabinol and Cannabidiol on Neural Activation During Emotional Processing
Effects of Cannabidiol (CBD) on Regional Cerebral Blood
Is cannabis treatment for anxiety, mood, and related disorders ready for prime time?
Neural basis of anxiolytic effects of cannabidiol (CBD) in generalized social anxiety disorder- a preliminary report
Overexpression of CB2 cannabinoid receptors decreased vulnerability to anxiety and impaired anxiolytic action of alprazolam in mice

Appetite

Endogenous cannabinoid system as a modulator of food intake
Endocannabinoids, feeding and suckling – from our perspective
Hypothalamic POMC neurons promote cannabinoid-induced feeding
The role of the endocannabinoid system in eating disorders- pharmacological implications
The cannabinoids an overview. Therapeutic implications in vomiting and nausea after cancer chemotherapy, in appetite promotion, in multiple sclerosis and in neuroprotection

Arthritis

Cannabinoid receptor 2 as a potential therapeutic target in rheumatoid arthritis
Characterisation of the Cannabinoid Receptor System in Synovial Tissue and Fluid in Patients With Osteoarthritis and Rheumatoid Arthritis
Cannabinoid WIN-55,212-2 mesylate inhibits interleukin-1b induced matrix metalloproteinase and tissue inhibitor of matrix metalloproteinase expression in human chondrocytes
Cannabinoid CB2 Receptors Regulate Central Sensitization and Pain Responses Associated with Osteoarthritis of the Knee Joint

Asthma

Evaluation of Serum Cytokines Levels and the Role of Cannabidiol Treatment in Animal Model of Asthma

Attention Deficit Hyperactivity Disorder (ADHD)

Association of the Cannabinoid Receptor Gene (CNR1) With ADHD and Post-Traumatic Stress Disorder
Cannabinoid-induced conditioned place preference in the spontaneously hypertensive rat–an animal model of attention deficit hyperactivity disorder
Cannabis improves symptoms of ADHD
Drug Reinforcement in a Rat Model of Attention Deficit-Hyperactivity Disorder – The Spontaneously Hypertensive Rat (SHR)
Methods of the Pharmacological Imaging of the Cannabinoid System (PhICS) study- towards understanding the role of the brain endocannabinoid system in human cognition

Autism

Autism-Associated Neuroligin-3 Mutations Commonly Disrupt Tonic Endocannabinoid Signaling
Alterations in the endocannabinoid system in the rat valproic acid model of autism
Cannabinoid Receptor Type 2, but not Type 1, is Up-Regulated in Peripheral Blood Mononuclear Cells of Children Affected by Autistic Disorders
Consequences of Cannabinoid and Monoaminergic System Disruption in a Mouse Model of Autism Spectrum Disorders
Deficient Social and Play Behavior in Juvenile and Adult Rats after Neonatal Cortical Lesion- Effects of Chronic Pubertal Cannabinoid Treatment
Endocannabinoid System as Novel Therapeutic Target for Autism Treatment
Method for predicting autism spectrum disorders by cannabinoid and cannabinoid receptor expression
Species differences in cannabinoid receptor 2 (CNR2 gene)- identification of novel human and rodent CB2 isoforms, differential tissue expression and regulation by cannabinoid receptor ligands
Use of dronabinol (delta-9-THC) in autism- A prospective single-case-study with an early infantile autistic child
Uncoupling of the endocannabinoid signaling complex in a mouse model of fragile X syndrome
Variation in the human cannabinoid receptor CNR1 gene modulates gaze duration for happy faces

Autoimmune

Cannabidiol Arrests Onset of Autoimmune Diabetes in NOD Mice
Cannabinoids as novel anti-inflammatory drugs
Role of Myeloid-Derived Suppressor Cells in Amelioration of Experimental Autoimmune Hepatitis Following Activation of TRPV1 Receptors by Cannabidiol

Batten Disease

Cannabidiol Reduces Aβ-Induced Neuroinflammation and Promotes Hippocampal Neurogenesis through PPARγ Involvement
Cannabidiol provides long-lasting protection against the deleterious effects of inflammation in a viral model of multiple sclerosis- A role for A2A receptors
Cannabinoid inhibits HIV-1 Tat-stimulated adhesion of human monocyte-like cells to extracellular matrix proteins
Cannabidiol reduces lipopolysaccharide-induced vascular changes and inflammation in the mouse brain- an intravital microscopy study
Cannabidiol reduces host immune response and prevents cognitive impairments in Wistar rats submitted to pneumococcal meningitis
siRNA knockdown of GPR18 receptors in BV-2 microglia attenuates N-arachidonoyl glycineinduced cell migration

Breast Cancer

Antitumor Activity of Plant Cannabinoids with Emphasis on the Effect of Cannabidiol on Human Breast Carcinoma
Cannabinoids- A new hope for breast cancer therapy
Cannabidiol Induces Programmed Cell Death in Breast Cancer Cells by Coordinating the Cross-talk between Apoptosis and Autophagy
Cannabinoids reduce ErbB2-driven breast cancer progression through Akt inhibition
Cannabidiol as a novel inhibitor of Id-1 gene expression in aggressive breast cancer cells
Modulation of breast cancer cell viability by a cannabinoid receptor 2 agonist, JWH-015, is calcium dependent
Pathways mediating the effects of cannabidiol on the reduction of breast cancer cell proliferation, invasion, and metastasis
Synthetic cannabinoid receptor agonists inhibit tumor growth and metastasis of breast cancer
Targeting multiple cannabinoid anti-tumour pathways with a resorcinol derivative leads to inhibition of advanced stages of breast cancer
The endogenous cannabinoid anandamide inhibits human breast cancer cell proliferation

Cancer

Anticancer mechanisms of cannabinoids
Antitumor Activity of Plant Cannabinoids with Emphasis on the Effect of Cannabidiol on Human Breast Carcinoma
A cannabinoid quinone inhibits angiogenesis by targeting vascular endothelial cells
Anandamide Induces Apoptosis in Human Cells via Vanilloid Receptors
Anti-proliferative effects of anandamide in human hepatocellular carcinoma cells
A pilot clinical study of D9-tetrahydrocannabinol in patients with recurrent glioblastoma multiforme
Antitumorigenic Effects of Cannabinoids beyond Apoptosis
Antiangiogenic activity of the endocannabinoid anandamide- Correlation to its tumor-suppressor efficacy
Anti-tumoral action of cannabinoids on hepatocellular carcinoma- role of AMPK-dependent activation of autophagy
Anti-tumoral action of cannabinoids- Involvement of sustained ceramide accumulation and extracellular signal-regulated kinase activation
Cannabidiol inhibits lung cancer cell invasion and metastasis via intercellular adhesion molecule-1
Cannabidiol Inhibits Cancer Cell Invasion Via Upregulation Of Tissue Inhibitor Of Matrix Metalloproteinases-1
Cannabinoids as therapeutic agents in cancer- current status and future implications
Clinical Significance of Cannabinoid Receptors CB1 and CB2 Expression in Human Malignant and Benign Thyroid Lesions
Cannabinoid receptors as novel targets for the treatment of melanoma
Cannabidiol Inhibits Growth and Induces Programmed Cell Death in Kaposi Sarcoma–Associated Herpesvirus Infected Endothelium
COX-2 and PPAR-g Confer Cannabidiol-Induced Apoptosis of Human Lung Cancer Cells
Cannabinoids induce apoptosis of pancreatic tumor cells via endoplasmic reticulum stress-related genes
Cannabinoid Receptors, CB1 and CB2, as Novel Targets for Inhibition of Non-Small Cell Lung Cancer Growth and Metastasis
Cannabidiol as potential anticancer drug
Cannabinoids and omega-3-6 endocannabinoids as cell death and anticancer modulators
Cannabinoid-associated cell death mechanisms in tumor models (Review)
Cannabinoid Receptor Agonist as an Alternative Drug in 5-Fluorouracil-resistant Gastric Cancer Cells
Cannabis in Cancer Care
Cannabinoids Protect Astrocytes from Ceramide-induced Apoptosis through the Phosphatidylinositol 3-Kinase-Protein Kinase B Pathway
Cannabinoid receptor-dependent and -independent anti-proliferative effects of omega-3 ethanolamides in androgen receptor-positive and -negative prostate cancer cell lines
Cannabinoids, Endocannabinoids and Cancer
Cannabidiol (CBD) Priming Enhances Cisplatin Killing Of Cancer Cells
Cannabis Extract Treatment for Terminal Acute Lymphoblastic Leukemia with a Philadelphia Chromosome Mutation
Cannabinoid Receptor-Mediated Apoptosis Induced by R()-Methanandamide and Win55,212-2 Is Associated with Ceramide Accumulation and p38 Activation in Mantle Cell Lymphoma
Ceramide- a new second messenger of cannabinoid action
Cannabinoids- potential antitumoral agents
Cannabinoids and cancer- pros and cons of an antitumour strategy
Cannabis and Cannabinoids (PDQ®) - National Cancer Institute
Cannabinoids and ceramide- Two lipids acting hand-by-hand
Cannabinoid receptor ligands as potential anticancer agents – high hopes for new therapies
Cannabinoids for Cancer Treatment- Progress and Promise
CBD inhibits angiogenesis by multiple mechanisms
Cannabinoids and Cancer
Cannabinoid receptor 1 is a potential drug target for treatment of translocation-positive rhabdomyosarcoma
Cannabidiol Enhances the Inhibitory Effects of D9-Tetrahydrocannabinol on Human Glioblastoma Cell Proliferation and Survival
Differential role of cannabinoids in the pathogenesis of skin cancer
Expression and Functional Relevance of Cannabinoid Receptor 1 in Hodgkin Lymphoma
Exogenous hepatitis B virus envelope proteins induce endoplasmic reticulum stress- involvement of cannabinoid axis in liver cancer cells
Expression of cannabinoid receptors type 1 and type 2 in non-Hodgkin lymphoma- Growth inhibition by receptor activation
Endocannabinoids as emerging suppressors of angiogenesis and tumor invasion (Review)
Endocannabinoids as Guardians of Metastasis
Endocannabinoids and Cancer
Evaluation of the Cyclooxygenase Inhibiting Effects of Six Major Cannabinoids Isolated from Cannabis sativa
Endocannabinoids in endocrine and related tumours
Endocannabinoids and fatty acid amides in cancer inflammation and related disorders
Enhancing the Activity of Cannabidiol and Other Cannabinoids In Vitro Through Modifications to Drug Combinations and Treatment Schedules
High level of cannabinoid receptor 1, absence of regulator of G protein signalling 13 and differential expression of Cyclin D1 in mantle cell lymphoma
Id-1 Is a Key Transcriptional Regulator of Glioblastoma Aggressiveness and a Novel Therapeutic Target
Inhibition of skin tumor growth and angiogenesis in vivo by activation of cannabinoid receptors
Involvement of PPARc in the antitumoral action of cannabinoids on hepatocellular carcinoma
Inhibition of Cancer Cell Invasion by Cannabinoids via Increased Expression of Tissue Inhibitor of Matrix Metalloproteinases-1
In vitro and in vivo efficacy of non-psychoactive cannabidiol in neuroblastoma
Inhibition of tumor angiogenesis by cannabinoids
Integrating cannabis into clinical cancer care
Increasing Antiproliferative Properties of Endocannabinoids in N1E-115 Neuroblastoma Cells through Inhibition of Their Metabolism
Loss of Cannabinoid Receptor 1 Accelerates Intestinal Tumor Growth
Marijuana Use and the Risk of Lung and Upper Aerodigestive Tract Cancers- Results of a Population-Based Case-Control Study
Microarray and Pathway Analysis Reveal Distinct Mechanisms Underlying Cannabinoid-Mediated Modulation of LPS-Induced Activation of BV-2 Microglial Cells
Medical marijuana for cancer
Non-THC cannabinoids inhibit prostate carcinoma growth in vitro and in vivo- pro-apoptotic effects and underlying mechanisms
Proapoptotic effect of endocannabinoids in prostate cancer cells
Potentiation of the antitumor activity of adriamycin against osteosarcoma by cannabinoid WIN-55,212-2
Potentiation of Cannabinoid-Induced Cytotoxicity in Mantle Cell Lymphoma through Modulation of Ceramide Metabolism
Preparation and characterisation of biodegradable microparticles filled with THC and their antitumor efficacy on cancer cell lines
Receptor-dependent and receptor-independent endocannabinoid signaling- A therapeutic target for regulation of cancer growth
Synthetic cannabinoid receptor agonists inhibit tumor growth and metastasis of breast cancer
The potential relevance of the endocannabinoid, 2- arachidonoylglycerol, in diffuse large B-cell lymphoma
The use of cannabinoids as anticancer agents
Towards the use of cannabinoids as antitumour agents
The role of cannabinoids in prostate cancer- Basic science perspective and potential clinical applications
The effects of cannabidiol and its synergism with bortezomib in multiple myeloma cell lines. A role for transient receptor potential vanilloid type-2
The Expression Level of CB1 and CB2 Receptors Determines Their Efficacy at Inducing Apoptosis in Astrocytomas
The CB2 cannabinoid receptor signals apoptosis via ceramide-dependent activation of the mitochondrial intrinsic pathway
Targeting CB2-GPR55 Receptor Heteromers Modulates Cancer Cell Signaling
The Antitumor Activity of Plant-Derived Non-Psychoactive Cannabinoids
The stress-regulated protein p8 mediates cannabinoid-induced apoptosis of tumor cells
The endocannabinoid system and cancer- therapeutic implication
The endocannabinoid system in cancer- Potential therapeutic target
Targeting CB2 cannabinoid receptors as a novel therapy to treat malignant lymphoblastic disease
The endogenous cannabinoid anandamide inhibits human breast cancer cell proliferation
United States patent application publication for phytocannabinoids in the treatment of cancer
Δ9-Tetrahydrocannabinol inhibits epithelial growth factor-induced lung cancer cell migration in vitro as well as its growth and metastasis in vivo

Cannabidiol (CBD)

Action of Cannabidiol on the Anxiety and Other Effects Produced by D9-THC in Normal Subjects
An Update on Safety and Side Effects of Cannabidiol- A Review of Clinical Data and Relevant Animal Studies
Cannabidiol is a negative allosteric modulator of the type 1 cannabinoid receptor
Cannabidiol in Humans—The Quest for Therapeutic Targets
Cannabidiol- from an inactive cannabinoid to a drug with wide spectrum of action
Cannabidiol displays unexpectedly high potency as an antagonist of CB1 and CB2 receptor agonists in vitro
Cannabidiol- Promise and Pitfalls
Identification of Psychoactive Degradants of Cannabidiol in Simulated Gastric and Physiological Fluid
Safety and Side Effects of Cannabidiol, a Cannabis sativa Constituent
5-Lipoxygenase and anandamide hydrolase (FAAH) mediate the antitumor activity of cannabidiol, a non-psychoactive cannabinoid

Cardiovascular

Acute administration of cannabidiol in vivo suppresses ischaemia-induced cardiac arrhythmias and reduces infarct size when given at reperfusion
Blood pressure regulation by endocannabinoids and their receptors
Cyclooxygenase metabolism mediates vasorelaxation to 2-arachidonoylglycerol (2-AG) in human mesenteric arteries
Cannabinoids in experimental stroke- a systematic review and meta-analysis
Is the cardiovascular system a therapeutic target for cannabidiol
Oxyradical Stress, Endocannabinoids, and Atherosclerosis
Role of Endocannabinoids and Cannabinoid-1 Receptors in Cerebrocortical Blood Flow Regulation
STUDIES INVESTIGATING THE MECHANISMS OF THE CARDIOPROTECTIVE EFFECTS OF CANNABIDIOL
Therapeutic Potential of Non-Psychotropic Cannabidiol in Ischemic Stroke

CB1 Receptor

Allosteric Modulation of the Cannabinoid CB1 Receptor
Cannabidiol is a negative allosteric modulator of the type 1 cannabinoid receptor
Cannabinoid Receptors, CB1 and CB2, as Novel Targets for Inhibition of Non-Small Cell Lung Cancer Growth and Metastasis
Cannabinoid CB1 receptor binding and acetylcholinesterase inhibitory activity of Sceletium tortuosum L.
Cannabinoid receptor CB1-like and glutamic acid decarboxylase-like immunoreactivities in the brain of Xenopus laevis
Design, Synthesis, Biological Properties, and Molecular Modeling Investigations of Novel Tacrine Derivatives with a Combination of Acetylcholinesterase Inhibition and Cannabinoid CB1 Receptor Antagoni
Evidence for functional CB1 cannabinoid receptor expressed in the rat thyroid
Enhanced acetylcholine release in the hippocampus of cannabinoid
Immunohistochemical analysis of cannabinoid receptor 1 expression in steatotic rat livers
Loss of Cannabinoid Receptor 1 Accelerates Intestinal Tumor Growth
Presynaptically Located CB1 Cannabinoid Receptors Regulate GABA Release from Axon Terminals of Specific Hippocampal Interneurons

CB2 Receptor

Activation of cannabinoid receptor type II by AM1241 protects adipose-derived mesenchymal stem cells from oxidative damage
Cannabinoid Type 2 Receptors Mediate a Cell Type Specific Plasticity in the Hippocampus
CB2 cannabinoid receptors as an emerging target for demyelinating diseases- from neuroimmune interactions to cell replacement strategies
Direct suppression of autoreactive lymphocytes in the central nervous system via the CB2 receptor
Non-psychoactive CB2 cannabinoid agonists stimulate neural progenitor proliferation
Role of CB2 receptors in social and aggressive behavior in male mice
Treatment with CB2 Agonist JWH-133 Reduces Histological Features Associated with Erectile Dysfunction in Hypercholesterolemic Mice
Targeting CB2 receptors and the endocannabinoid system for the treatment of pain
The CB2 cannabinoid receptor signals apoptosis via ceramide-dependent activation of the mitochondrial intrinsic pathway
The serine hydrolases MAGL, ABHD6 and ABHD12 as guardians of 2-arachidonoylglycerol signalling through cannabinoid receptors

CBDV

Cannabidivarin-rich cannabis extracts are anticonvulsant in mouse and rat via a CB1 receptor-independent mechanism
Cannabidivarin (CBDV) suppresses pentylenetetrazole (PTZ)-induced increases in epilepsy-related gene expression

Cellular Function

Anti-inflammatory Potential of CB1-mediated CAMP Elevation in Mast Cells
Cannabidiol is a Potent Inhibitor of the Catalytic Activity of Cytochrome P450 2C19
Cannabidiol Targets Mitochondria to Regulate Intracellular Ca2 Levels
Characterization of P-glycoprotein Inhibition by Major Cannabinoids from Marijuana

Cerebral Palsy

Survey Results of Pain Treatments in Adults with Cerebral Palsy

Cognition

Cannabidiol reduces host immune response and prevents cognitive impairments in Wistar rats submitted to pneumococcal meningitis
Effects of cannabis on cognitive function in patients with multiple sclerosis
Keep off the grass Cannabis, cognition and addiction
Methods of the Pharmacological Imaging of the Cannabinoid System (PhICS) study- towards understanding the role of the brain endocannabinoid system in human cognition

Colon Cancer

Cannabinoid receptor activation induces apoptosis through tumor necrosis factor alpha-mediated ceramide de novo synthesis in colon cancer cells
Chemopreventive effect of the non-psychotropic phytocannabinoid cannabidiol on experimental colon cancer
Estrogenic induction of cannabinoid CB1 receptor in human colon cancer cell lines
Growth inhibition and induction of apoptosis in colorectal tumor cells by cyclooxygenase inhibitors
Induction of Apoptosis by Cannabinoids in Prostate and Colon Cancer Cells Is Phosphatase Dependent
Inhibition of colon carcinogenesis by a standardized Cannabis sativa extract with high content of cannabidiol
Possible endocannabinoid control of colorectal cancer growth
The cannabinoid δ9-tetrahydrocannabinol inhibits RAS-MAPK and PI3K-AKT survival signalling and induces BAD-mediated apoptosis in colorectal cancer cells
The endogenous cannabinoid, anandamide, induces COX-2-dependent cell death in apoptosis-resistant colon cancer cells
The endogenous cannabinoid, anandamide, induces cell death in colorectal carcinoma cells- a possible role for cyclooxygenase 2

Crohn's Disease

Cannabis Induces a Clinical Response in Patients With Crohn’s Disease- A Prospective Placebo-Controlled Study
Cannabis Finds Its Way into Treatment of Crohn’s Disease
Cannabis Alleviates Symptoms Of Crohn’s Disease
Treatment of Crohn’s Disease with Cannabis- An Observational Study

D9-Tetrahydrocannabinol (THC)

Activity of cannabis in relation to its delta'-trans-tetrahydro-cannabinol content
Antidepressant-like effect of D9-tetrahydrocannabinol and other cannabinoids isolated from Cannabis sativa L
A tale of two cannabinoids: The therapeutic rationale for combining tetrahydrocannabinol and cannabidiol
A pilot clinical study of D9-tetrahydrocannabinol in patients with recurrent glioblastoma multiforme
Antibacterial activity of D9_tetrahydrocannabinol and cannabidiol
Adolescent Exposure to Chronic Delta-9-Tetrahydrocannabinol Blocks Opiate Dependence in Maternally Deprived Rats
BRONCHODILATOR EFFECT OF D9-TETRAHYDROCANNABINOL
Cannabidiol and (−)Δ9-tetrahydrocannabinol are neuroprotective antioxidants
Cannabidiol Attenuates the Appetitive Effects of D9-Tetrahydrocannabinol in Humans Smoking Their Chosen Cannabis
Cannabidiol Enhances the Inhibitory Effects of D9-Tetrahydrocannabinol on Human Glioblastoma Cell Proliferation and Survival
D9-Tetrahydrocannabinol Prevents Methamphetamine-Induced Neurotoxicity
Dose-related differences in the regional pattern of cannabinoid receptor adaptation and in vivo tolerance development to delta9-tetrahydrocannabinol
Effect of D-9-Tetrahydrocannabinol and Cannabidiol on Nocturnal Sleep and Early-Morning Behavior in Young Adults
Fatty Acid Binding Proteins (FABPs) are Intracellular Carriers for D9-Tetrahydrocannabinol (THC) and Cannabidiol (CBD)
Histone Modifications Are Associated with Delta (9)-tetrahydrocannabinol-Mediated Alterations in Antigen-Specific T Cell Responses
Hemp Oil Ingestion Causes Positive Urine Tests for D9-Tetrahydrocannabinol Carboxylic Acid
Influence of Treatment of Tourette Syndrome with D9-Tetrahydrocannabinol (D9-THC) on Neuropsychological Performance
Long_term behavioral and biochemical effects of an ultra_low dose of D9_tetrahydrocannabinol (THC)- neuroprotection and ERK signaling
Marijuana, Tetrahydrocannabinol, and Pulmonary Antibacterial Defenses
Neuroprotective Effect of(−)Δ9-Tetrahydrocannabinol and Cannabidiol in N-Methyl-d-Aspartate-Induced Retinal Neurotoxicity
Neuroprotection by D9-Tetrahydrocannabinol, the Main Active Compound in Marijuana, against Ouabain-Induced In Vivo Excitotoxicity
Opposite Effects of D-9-Tetrahydrocannabinol and Cannabidiol on Human Brain Function and Psychopathology
Protective effects of Δ9-tetrahydrocannabinol against N-methyl-D-aspartate-induced AF5 cell death
Preliminary, open-label, pilot study of add-on oral D9-tetrahydrocannabinol in chronic post-traumatic stress disorder
The endocannabinoid system and emotional Processing- A pharmacological fMRI study with D9-tetrahydrocannabinol
The diverse CB1 and CB2 receptor pharmacology of three plant cannabinoids- Δ9-tetrahydrocannabinol, cannabidiol and Δ9-tetrahydrocannabivarin
Treatment of Tourette-Syndrome with D9-Tetrahydrocannabinol (THC)- a randomized crossover trial
Δ9-Tetrahydrocannabinol inhibits epithelial growth factor-induced lung cancer cell migration in vitro as well as its growth and metastasis in vivo

D9-Tetrahydrocannabinolic acid (THCA)

Can You Pass the Acid Test- Critical Review and Novel Therapeutic Perspectives of D9-Tetrahydrocannabinolic Acid A

Depression

Antidepressant-like effect of D9-tetrahydrocannabinol and other cannabinoids isolated from Cannabis sativa L
Antidepressant-Like and Anxiolytic-Like Effects of Cannabidiol- A Chemical Compound of Cannabis sativa
Cannabinoids promote embryonic and adult hippocampus neurogenesis and produce anxiolytic- and antidepressant-like effects

Diabetes

Cannabidiol attenuates cardiac dysfunction, oxidative stress, fibrosis, and inflammatory and cell death signaling pathways in diabetic cardiomyopathy
Cannabinoids Regulate Bcl-2 and Cyclin D2 Expression in Pancreatic β Cells
Cannabidiol Arrests Onset of Autoimmune Diabetes in NOD Mice
Effects of the cannabinoid-1 receptor blocker rimonabant on weight reduction and cardiovascular risk factors in overweight patients- 1-year experience from the RIO-Europe study
Novel Study Reports Marijuana Users Have Better Blood Sugar Control
Presence of functional cannabinoid receptors in human endocrine pancreas
The Endocannabinoid System and Plant-Derived Cannabinoids in Diabetes and Diabetic Complications
The Endogenous Cannabinoid System Stimulates Glucose Uptake in Human Fat Cells via Phosphatidylinositol 3-Kinase and Calcium Dependent Mechanisms
The endocannabinoid system in obesity and type 2 diabetes

Drug Interactions

A Phase I, open-label, randomized, crossover study in three parallel groups to evaluate the effect of Rifampicin, Ketoconazole, and Omeprazole on the pharmacokinetics of THC/CBD oromucosal spray in he
Cannabis and its effect on anesthesia
Interactions between cannabidiol and commonly used antiepileptic drugs

Edema

Sex differences in anti-allodynic, anti-hyperalgesic and anti-edema effects of Δ9-tetrahydrocannabinol in the rat

Emesis

Cannabidiolic acid prevents vomiting in Suncus murinus and nausea-induced behaviour in rats by enhancing 5-HT1A receptor activation
Cannabidiol, a non-psychotropic component of cannabis, attenuates vomiting and nausea-like behaviour via indirect agonism of 5-HT1A somatodendritic autoreceptors in the dorsal raphe nucleus
Interaction between non-psychotropic cannabinoids in marihuana- effect of cannabigerol (CBG) on the anti-nausea or anti-emetic effects of cannabidiol (CBD) in rats and shrews
Regulation of nausea and vomiting by cannabinoids
The Nonpsychoactive Cannabinoid Cannabidiol Inhibits 5-Hydroxytryptamine3A Receptor-Mediated Currents in Xenopus laevis Oocytes
The effects of cannabidiol and tetrahydrocannabinol on motion-induced emesis in Suncus murinus

Endocannabinoid System (ECS)

Abnormalities in neuroendocrine stress response in psychosis- the role of endocannabinoids
An Update on Non-CB1, Non-CB2 Cannabinoid Related G-Protein-Coupled Receptors
Agonistic Properties of Cannabidiol at 5-HT1a Receptors
Antiangiogenic activity of the endocannabinoid anandamide- Correlation to its tumor-suppressor efficacy
Anandamide and 2-arachidonoylglycerol- pharmacological properties, functional features, and emerging specificities of the two major endocannabinoids
Biphasic Effects of Cannabinoids on Acetylcholine Release in the Hippocampus- Site and Mechanism of Action
Cannabinoid Receptors CB1 and CB2 Form Functional Heteromers in Brain
Cannabis and endocannabinoid modulators- Therapeutic promises and challenges
Clinical endocannabinoid deficiency (CECD) revisited- Can this concept explain the therapeutic benefits of cannabis in migraine, fibromyalgia, irritable bowel syndrome and other treatment-resistant co
Cannabinoid-induced mesenteric vasodilation through an endothelial site distinct from CB1 or CB2 receptors
Clinical Endocannabinoid Deficiency (CECD)- Can this Concept Explain Therapeutic Benefits of Cannabis in Migraine, Fibromyalgia, Irritable Bowel Syndrome and other Treatment-Resistant Conditions
Cannabinoid Receptors and Endocannabinoids- Evidence for New Players
Care and Feeding of the Endocannabinoid System- A Systematic Review of Potential Clinical Interventions that Upregulate the Endocannabinoid System
Cannabidiol displays unexpectedly high potency as an antagonist of CB1 and CB2 receptor agonists in vitro
Cannabidiol is an allosteric modulator at mu- and delta-opioid receptors
Clinical Endocannabinoid Deficiency Reconsidered- Current Research Supports the Theory in Migraine, Fibromyalgia, Irritable Bowel, and Other Treatment-Resistant Syndromes
Cannabinoid system and cyclooxygenases inhibitors
Cannabis, a complex plant- different compounds and different effects on individuals
Cannabinoid pharmacology- the first 66 years
Cannabinoid receptors and their ligands
Dose-related differences in the regional pattern of cannabinoid receptor adaptation and in vivo tolerance development to delta9-tetrahydrocannabinol
Estrogen Receptor Beta and 2-arachidonoylglycerol Mediate the Suppressive Effects of Estradiol on Frequency of Postsynaptic Currents
Endocannabinoid binding to the cannabinoid receptors- what is known and what remains unknown
Endocannabinoid Signaling Regulates Sleep Stability
Endocannabinoid signalling and the deteriorating brain
Endocannabinoid CB1 receptor-mediated rises in Ca2+ and depolarization-induced suppression of inhibition
Endocannabinoids and the haematological system
Enhanced discriminative stimulus effects of 9-THC in the presence of cannabidiol and 8-OH-DPAT in rhesus monkeys
Endocannabinoids and energy homeostasis- An update
Endothelium-dependent metabolism by endocannabinoid hydrolases and cyclooxygenases limits vasorelaxation to anandamide and 2-arachidonoylglycerol
Endocannabinoid System in First Trimester Placenta- Low FAAH and High CB1 Expression Characterize Spontaneous Miscarriage
Evidence that the plant cannabinoid cannabigerol is a highly potent a2-adrenoceptor agonist and moderately potent 5HT1A receptor antagonist
Evidence for a physiological role of endocannabinoids in the modulation of seizure threshold and severity
Fatty Acid Binding Proteins (FABPs) are Intracellular Carriers for D9-Tetrahydrocannabinol (THC) and Cannabidiol (CBD)
Hardwiring the Brain- Endocannabinoids Shape Neuronal Connectivity
Identification of cytochrome P450 enzymes responsible for metabolism of cannabidiol by human liver microsomes
Mitochondria- a possible nexus for the regulation of energy homeostasis by the endocannabinoid system
Modulating the endocannabinoid system in human health and disease- successes and failures
Neuropharmacology of the Endocannabinoid Signaling System-Molecular Mechanisms, Biological Actions and Synaptic Plasticity
Pharmacokinetics and metabolism of the plant cannabinoids, delta9-tetrahydrocannabinol, cannabidiol and cannabinol
Role of the Cannabinoid System in Pain Control and Therapeutic Implications for the Management of Acute and Chronic Pain Episodes
Relationships between eicosanoids and cannabinoids- Are eicosanoids cannabimimetic agents-
Role of the Endocannabinoid System in the Neuroendocrine Responses to Inflammation
Recent advances in cannabinoid receptor agonists and antagonists
The endogenous cannabinoid system and its role in nociceptive behavior
The role of endogenous cannabinoids in the hypothalamo-pituitary-adrenal axis regulation- in vivo and in vitro studies in CB1 receptor knockout mice
The therapeutic potential of novel cannabinoid receptors
Targeting the endocannabinoid system with cannabinoid receptor agonists- pharmacological strategies and therapeutic possibilities
The Endocannabinoid-CB Receptor System- Importance for development and in pediatric disease
The endocannabinoid system- a new target for the regulation of energy balance and metabolism
The endocannabinoid system drives neural progenitor proliferation
The diverse CB1 and CB2 receptor pharmacology of three plant cannabinoids- Δ9-tetrahydrocannabinol, cannabidiol and Δ9-tetrahydrocannabivarin
The orphan receptor GPR55 is a novel cannabinoid receptor
The endocannabinoid system and migraine
The Endocannabinoid System as an Emerging Target of Pharmacotherapy
The endocannabinoid system in normal and pathological brain ageing
The Endocannabinoid System, Cannabinoids, and Pain
The Emerging Role of the Endocannabinoid System in Endocrine Regulation and Energy Balance

Endocrine System

Estrogen Receptor Beta and 2-arachidonoylglycerol Mediate the Suppressive Effects of Estradiol on Frequency of Postsynaptic Currents
Estrogenic induction of cannabinoid CB1 receptor in human colon cancer cell lines
Gynecomastia and cannabis smoking- A nonassociation among US Army soldiers
Marijuana- interaction with the estrogen receptor
Presence of functional cannabinoid receptors in human endocrine pancreas
The effects of delta9-tetrahydrocannabinol and cannabidiol on the metabolism of gonadal steroids in the rat
The Emerging Role of the Endocannabinoid System in Endocrine Regulation and Energy Balance

Epilepsy

Assessment of the role of CB receptors in cannabinoid 1 anticonvulsant effects
Analysis of endocannabinoid signaling elements and related proteins in lymphocytes of patients with Dravet syndrome
Activation of the Cannabinoid Type-1 Receptor Mediates the Anticonvulsant Properties of Cannabinoids in the Hippocampal Neuronal Culture Models of Acquired Epilepsy and Status Epilepticus
Cannabidiol displays antiepileptiform and antiseizure properties in vitro and in vivo
Cannabidivarin-rich cannabis extracts are anticonvulsant in mouse and rat via a CB1 receptor-independent mechanism
Cannabidiol in patients with seizures associated with Lennox-Gastaut syndrome (GWPCARE4) a randomised, double-blind, placebo-controlled phase 3 trial
Cannabidiol Rescues Acute Hepatic Toxicity and Seizure Induced by Cocaine
Chronic Administration of Cannabidiol to Healthy Volunteers and Epileptic Patients
CANNABIS IN THE MANAGEMENT AND TREATMENT OF SEIZURES AND EPILEPSY- A SCIENTIFIC REVIEW
Cannabidivarin is anticonvulsant in mouse and rat
Cannabidivarin (CBDV) suppresses pentylenetetrazole (PTZ)-induced increases in epilepsy-related gene expression
Cannabinoids for pediatric epilepsy- Up in smoke or real science-
Cannabidiol exerts anti-convulsant effects in animal models of temporal lobe and partial seizures
Cannabis, Cannabinoids and Tinnitus
Cannabidiol Post-Treatment Alleviates Rat Epileptic-Related Behaviors and Activates Hippocampal Cell Autophagy Pathway Along with Antioxidant Defense in Chronic Phase of Pilocarpine-Induced Seizure
CBD-enriched medical cannabis for intractable pediatric epilepsy
Cannabinoids in the Treatment of Epilepsy
Cilio The case for assessing cannabidiol in epilepsy Epilepsia 2014
Devinsky Cannabidol pharmacology and therapeutic role in epilepsy and other neuropsychiatric disorders Epilepsia 2014
Evidence for a physiological role of endocannabinoids in the modulation of seizure threshold and severity
Epidiolex (Cannabidiol) in Treatment Resistant Epilepsy
Hill Sodium channel blockade by cannabinoids does not confer anticonvulsant effects Neurosci Letters 2014
Lorenz- Cannabis Pediatrics Epilepsy NEL 2004
Maa The case for medical marijuana in epilepsy Epilepsia 2014
Marijuana Use in Epilepsy- The Myth and the Reality
Redistribution of CB1 Cannabinoid Receptors in the Acute and Chronic Phases of Pilocarpine-Induced Epilepsy
Report of a parent survey of cannabidiol-enriched cannabis use in pediatric treatment-resistant epilepsy
Treat et al. (2017)-Duration of use of oral cannabis extract in a cohort of pediatric epilepsy patients
The current status of artisanal cannabis for the treatment of epilepsy in the United States
The Pharmacological Basis of Cannabis Therapy for Epilepsy
The Endogenous Cannabinoid System Regulates Seizure Frequency and Duration in a Model of Temporal Lobe Epilepsy
Trial of Cannabidiol for Drug-Resistant Seizures in the Dravet Syndrome
Understanding Cannabinoids and Epilepsy

Fibromyalgia

Association of Herbal Cannabis Use With Negative Psychosocial Parameters in Patients With Fibromyalgia
Marijuana Rated Most Effective for Treating Fibromyalgia

Fibrosis

Cannabinoids, inflammation, and fibrosis
Cannabinoids and Cystic Fibrosis- A Novel Approach to Etiology and Therapy
Cannabinoids and Cystic Fibrosis- A Novel Approach to Etiology and Therapy
Cannabinoids and Cystic Fibrosis- A Novel Approach to Etiology and Therapy

Gastrointestinal Disease

Beneficial effect of the non-psychotropic plant cannabinoid cannabigerol on experimental inflammatory bowel disease
Cannabidiol Reduces Intestinal Inflammation through the Control of Neuroimmune Axis
Cannabis Induces a Clinical Response in Patients With Crohn’s Disease- A Prospective Placebo-Controlled Study
Cannabis use amongst patients with inflammatory bowel disease
Cannabinoids and the gastrointestinal tract
Cannabidiol in Inflammatory Bowel Diseases- A Brief Overview
Cannabis Alleviates Symptoms Of Crohn’s Disease
Cannabis Finds Its Way into Treatment of Crohn’s Disease
Ghrelin and cannabinoids require the ghrelin receptor to affect cellular energy metabolism
Marijuana Use Patterns Among Patients with Inflammatory Bowel Disease
Pro-resolution, protective and anti-nociceptive effects of a cannabis extract in the rat gastrointestinal tract
The effects of Δ9-tetrahydrocannabinol and cannabidiol alone and in combination on damage, inflammation and in vitro motility disturbances in rat colitis
Treatment of Crohn’s Disease with Cannabis- An Observational Study

General

Acute Pulmonary Physiologic Effects of Smoked Marijuana and Oral Δ9-Tetrahydrocannabinol in Healthy Young Men
Associations between Adolescent Cannabis Use and Neuropsychological Decline- A Longitudinal Co-Twin Control Study
Cannabis sativa- The Plant of the Thousand and One Molecules
Carliner et al (2017) - Cannabis use, attitudes, and legal status in the U.S.- A review
Cannabidiol- from an inactive cannabinoid to a drug with wide spectrum of action
Cannabis and Eicosanoids- A Review of Molecular Pharmacology
Cannabinoids in health and disease
Chemical constituents of marijuana- The complex mixture of natural cannabinoids
Chemistry, Metabolism, and Toxicology of Cannabis- Clinical Implications
Early phytocannabinoid chemistry to endocannabinoids and beyond
Future of Cannabis and Cannabinoids in Therapeutics
Medical Marijuana- Clearing Away the Smoke
Non-psychotropic plant cannabinoids- new therapeutic opportunities from an ancient herb
Plant cannabinoids- a neglected pharmacological treasure trove
Phytocannabinoids beyond the Cannabis plant – do they exist
Pharmacological actions and therapeutic uses of cannabis and cannabinoids
Review on clinical studies with cannabis and cannabinoids 2010-2014
Therapeutic aspects of cannabis and cannabinoids
The Therapeutic Potential of Cannabis and Cannabinoids
Toward Drugs Derived from Cannabis
Therapeutic Benefits of Cannabis- A Patient Survey

Glaucoma

Cannabinoids and glaucoma
Effect of sublingual application of cannabinoids on intraocular pressure- a pilot study
Neuroprotective Effect of(−)Δ9-Tetrahydrocannabinol and Cannabidiol in N-Methyl-d-Aspartate-Induced Retinal Neurotoxicity

Glioblastoma

A pilot clinical study of D9-tetrahydrocannabinol in patients with recurrent glioblastoma multiforme
Cannabinoids selectively inhibit proliferation and induce death of cultured human glioblastoma multiforme cells
Cannabidiol Enhances the Inhibitory Effects of D9-Tetrahydrocannabinol on Human Glioblastoma Cell Proliferation and Survival
Delta 9-tetrahydrocannabinol inhibits cell cycle progression by downregulation of E2F1 in human glioblastoma multiforme cells
Id-1 Is a Key Transcriptional Regulator of Glioblastoma Aggressiveness and a Novel Therapeutic Target

Glioma

A Combined Preclinical Therapy of Cannabinoids and Temozolomide against Glioma
Cannabidiol, a Non-Psychoactive Cannabinoid Compound, Inhibits Proliferation and Invasion in U87-MG and T98G Glioma Cells through a Multitarget Effect
Cannabinoids as potential new therapy for the treatment of gliomas
Cannabinoid action induces autophagy-mediated cell death through stimulation of ER stress in human glioma cells
Cannabinoids Inhibit the Vascular Endothelial Growth Factor Pathway in Gliomas
Cannabinoids Inhibit Glioma Cell Invasion by Down-regulating Matrix Metalloproteinase-2 Expression
Cannabidiol inhibits human glioma cell migration through a cannabinoid receptor-independent mechanism
D9-Tetrahydrocannabinol induces apoptosis in C6 glioma cells
Inhibition of Glioma Growth in Vivo by Selective Activation of the CB2 Cannabinoid Receptor
Safety and efficacy of a novel cannabinoid chemotherapeutic, KM-233, for the treatment of high-grade glioma
Systematic review of the literature on clinical and experimental trials on the antitumor effects of cannabinoids in gliomas
The Combination of Cannabidiol and D9 -Tetrahydrocannabinol Enhances the Anticancer Effects of Radiation in an Orthotopic Murine Glioma Model

HIV

Cannabinoid Receptor 2-Mediated Attenuation of CXCR4-Tropic HIV Infection in Primary CD4+ T Cells
Cannabinoid inhibits HIV-1 Tat-stimulated adhesion of human monocyte-like cells to extracellular matrix proteins
Cannabis in painful HIV-associated sensory neuropathy- a randomized placebo-controlled trial
Cannabis use in HIV for pain and other medical symptoms
Dronabinol and marijuana in HIV+ marijuana smokers- acute effects on caloric intake and mood
Marijuana smoking does not accelerate progression of liver disease in HIV-hepatitis C coinfection- a longitudinal cohort analysis
No significant effect of cannabis use on the count and percentage of circulating CD4 T-cells in HIV-HCV co-infected patients (ANRS CO13-HEPAVIH French cohort)
Short-term effects of cannabinoids in patients with HIV-1 infection- a randomized, placebo-controlled clinical trial

Huntington's Disease

Structure, expression and regulation of the cannabinoid receptor gene (CB1) in Huntington's disease transgenic mice
The pattern of neurodegeneration in Huntington's disease- a comparative study of cannabinoid, dopamine, adenosine and GABAA receptor alterations in the human basal ganglia in Huntington's disease

Immune Function

Cannabinoid receptor activation leads to massive mobilization of myeloid-derived suppressor cells with potent immunosuppressive properties
Cannabidiol reduces host immune response and prevents cognitive impairments in Wistar rats submitted to pneumococcal meningitis
Cannabinoid-induced apoptosis in immune cells as a pathway to immunosuppression
CB2 cannabinoid receptors as an emerging target for demyelinating diseases- from neuroimmune interactions to cell replacement strategies
Cannabinoids and the immune system- Potential for the treatment of inflammatory diseases
Cannabinoids, Immune System and Cytokine Network
Cannabinoids and the immune system
D9-Tetrahydrocannabinol-Induced Apoptosis in the Thymus and Spleen as a Mechanism of Immunosuppression in Vitro and in Vivo
Expression of central and peripheral cannabinoid receptors in human immune tissues and leukocyte subpopulations
Histone Modifications Are Associated with Delta (9)-tetrahydrocannabinol-Mediated Alterations in Antigen-Specific T Cell Responses
Immunoactive effects of cannabinoids- considerations for the therapeutic use of cannabinoid receptor agonists and antagonists
Interaction Between The Protective Effects Of Cannabidiol And Palmitoylethanolamide In Experimental Model Of Multiple Sclerosis In C57bl6 Mice

Infant Development

Endocannabinoids potently protect the newborn brain against AMPA-kainate receptor-mediated excitotoxic damage
Endocannabinoids, feeding and suckling – from our perspective
The Endocannabinoid-CB Receptor System- Importance for development and in pediatric disease

Inflammation

Anti-inflammatory effects of the cannabidiol derivative dimethylheptyl-cannabidiol – studies in BV-2 microglia and encephalitogenic T cells
Anti-Inflammatory Role of Cannabidiol and O-1602 in Cerulein-Induced Acute Pancreatitis in Mice
Cannabinoid receptor 2 as a potential therapeutic target in rheumatoid arthritis
Cannabinoids suppress inflammatory and neuropathic pain by targeting α3 glycine receptors
Cannabidiol Reduces Aβ-Induced Neuroinflammation and Promotes Hippocampal Neurogenesis through PPARγ Involvement
Cannabidiol provides long-lasting protection against the deleterious effects of inflammation in a viral model of multiple sclerosis- A role for A2A receptors
Cannabinoids in models of chronic inflammatory conditions
Cannabidiol exerts sebostatic and antiinflammatory effects on human sebocytes
Cannabidiol Reduces Intestinal Inflammation through the Control of Neuroimmune Axis
Cannabidiol as an Emergent Therapeutic Strategy for Lessening the Impact of Inflammation on Oxidative Stress
Cannabidiol attenuates cardiac dysfunction, oxidative stress, fibrosis, and inflammatory and cell death signaling pathways in diabetic cardiomyopathy
Cannabinoids Reduce Markers of Inflammation and Fibrosis in Pancreatic Stellate Cells
Cannabidiol (CBD) and its analogs a review of their effects
Cannabinoids mediate opposing effects on inflammation-induced intestinal permeability
Cannabidiol reduces lipopolysaccharide-induced vascular changes and inflammation in the mouse brain- an intravital microscopy study
Cannabinoid CB2 receptors in human brain inflammation
Clinical Implications for Cannabinoid Use in the Rheumatic Diseases
Cannabinoids as novel anti-inflammatory drugs
Cannabinoid CB2receptors in the gastrointestinaltract- a regulatory system in states of inflammation
Cannabinoids, Endocannabinoids, and Related Analogs in Inflammation
Cannabinoids and the immune system- Potential for the treatment of inflammatory diseases
Cannabinomimetic Control of Mast Cell Mediator Release- New Perspective in Chronic Inflammation
Cannabinoids, inflammation, and fibrosis
CANNABINOID-BASED DRUGS AS ANTI-INFLAMMATORY THERAPEUTICS
Evaluation of the Cyclooxygenase Inhibiting Effects of Six Major Cannabinoids Isolated from Cannabis sativa
Endocannabinoids and fatty acid amides in cancer inflammation and related disorders
Overcoming the Bell‐Shaped Dose‐Response of Cannabidiol by Using Cannabis Extract Enriched in Cannabidiol
Oxyradical Stress, Endocannabinoids, and Atherosclerosis
Modulation of Inflammatory Responses by a Cannabinoid-2–Selective Agonist after Spinal Cord Injury
Role of Myeloid-Derived Suppressor Cells in Amelioration of Experimental Autoimmune Hepatitis Following Activation of TRPV1 Receptors by Cannabidiol
Role of the Endocannabinoid System in the Neuroendocrine Responses to Inflammation
Sex differences in anti-allodynic, anti-hyperalgesic and anti-edema effects of Δ9-tetrahydrocannabinol in the rat
Suppression of human macrophage interleukin-6 by a nonpsychoactive cannabinoid acid
The endocannabinoid 2-AG protects the blood–brain barrier after closed head injury and inhibits mRNA expression of proinflammatory cytokines
The CB2 cannabinoid receptor-selective agonist O-3223 reduces pain and inflammation without apparent cannabinoid behavioral effects
The effects of Δ9-tetrahydrocannabinol and cannabidiol alone and in combination on damage, inflammation and in vitro motility disturbances in rat colitis

Ischemia

Activation of Cannabinoid CB2 Receptor–Mediated AMPK-CREB Pathway Reduces Cerebral Ischemic Injury
Acute administration of cannabidiol in vivo suppresses ischaemia-induced cardiac arrhythmias and reduces infarct size when given at reperfusion
Cannabidiol, a nonpsychoactive Cannabis constituent, protects against myocardial ischemic reperfusion injury
Cannabidiol administration after hypoxia-ischemia to newborn rats reduces long-term brain injury and restores neurobehavioral function
Effects of Cannabidiol and Hypothermia on Short-Term Brain Damage in New-Born Piglets after Acute Hypoxia-Ischemia
HU_211, a Novel Noncompetitive N_Methyl_D_Aspartate Antagonist, Improves Neurological Deficit and Reduces Infarct Volume After Reversible Focal Cerebral Ischemia in the Rat
Mechanisms of cannabidiol neuroprotection in hypoxic-ischemic newborn pigs- Role of 5HT1A and CB2 receptors
Therapeutic potential of cannabidiol against ischemia-reperfusion liver injury in rats
The Cannabinoid WIN55212-2 Promotes Neural Repair After Neonatal Hypoxia–Ischemia
The Cannabinoid Agonist Win55212 Reduces Brain Damage in an In Vivo Model of Hypoxic-Ischemic Encephalopathy in Newborn Rats
Therapeutic Potential of Non-Psychotropic Cannabidiol in Ischemic Stroke
Update on the Role of Cannabinoid Receptors after Ischemic Stroke

Kidney

Cannabidiol Attenuates Cisplatin-Induced Nephrotoxicity by Decreasing Oxidative-Nitrosative Stress, Inflammation, and Cell Death
Recreational Marijuana Use is Not Associated with Worse Outcomes After Renal Transplantation

Krabbe disease

Cannabinoids as novel anti-inflammatory drugs
Cannabinoids inhibit neurodegeneration in models of multiple sclerosis
CB2 cannabinoid receptors as an emerging target for demyelinating diseases- from neuroimmune interactions to cell replacement strategies
Experimental autoimmune encephalomyelitis disrupts endocannabinoid-mediated neuroprotection
Direct suppression of autoreactive lymphocytes in the central nervous system via the CB2 receptor
The Endocannabinoid System Is Dysregulated in Multiple Sclerosis and in Experimental Autoimmune Encephalomyelitis
Therapeutic Action of Cannabinoids in a Murine Model of Multiple Sclerosis
The endocannabinoid system as a target for the treatment of neurodegenerative disease

Leukemia

Dronabinol has preferential antileukemic activity in acute lymphoblastic and myeloid leukemia with lymphoid differentiation patterns
D9-Tetrahydrocannabinol-Induced Apoptosis in Jurkat Leukemia T Cells Is Regulated by Translocation of Bad to Mitochondria
Enhancing the Activity of Cannabidiol and Other Cannabinoids In Vitro Through Modifications to Drug Combinations and Treatment Schedules

Liver

Cannabidiol protects liver from binge alcohol-induced steatosis by mechanisms including inhibition of oxidative stress and increase in autophagy
Cannabidiol improves brain and liver function in a fulminant hepatic failure-induced model of hepatic encephalopathy in mice
Endocannabinoids in Liver Disease
Identification of cytochrome P450 enzymes responsible for metabolism of cannabidiol by human liver microsomes
Exogenous hepatitis B virus envelope proteins induce endoplasmic reticulum stress- involvement of cannabinoid axis in liver cancer cells
Protective effect of cannabidiol against cadmium hepatotoxicity in rats
Role of Myeloid-Derived Suppressor Cells in Amelioration of Experimental Autoimmune Hepatitis Following Activation of TRPV1 Receptors by Cannabidiol

Lung Cancer

Cannabidiol inhibits lung cancer cell invasion and metastasis via intercellular adhesion molecule-1
Cannabidiol Inhibits Cancer Cell Invasion Via Upregulation Of Tissue Inhibitor Of Matrix Metalloproteinases-1
Cannabinoids for Cancer Treatment- Progress and Promise
Cannabinoid Receptors, CB1 and CB2, as Novel Targets for Inhibition of Non-Small Cell Lung Cancer Growth and Metastasis
COX-2 and PPAR-g Confer Cannabidiol-Induced Apoptosis of Human Lung Cancer Cells
Marijuana Use and the Risk of Lung and Upper Aerodigestive Tract Cancers- Results of a Population-Based Case-Control Study
Pathways mediating the effects of cannabidiol on the reduction of breast cancer cell proliferation, invasion, and metastasis
Δ9-Tetrahydrocannabinol inhibits epithelial growth factor-induced lung cancer cell migration in vitro as well as its growth and metastasis in vivo

Lupus

Cannabinoids, inflammation, and fibrosis
Effects of cannabinoids on LPS-stimulated inflammatory mediator release from macrophages- Involvement of eicosanoids
Endogenous Interleukin-1 Receptor Antagonist Mediates Anti-Inflammatory and Neuroprotective Actions of Cannabinoids in Neurons and Glia
Recent advances in cannabinoid receptor agonists and antagonists
Suppression of human macrophage interleukin-6 by a nonpsychoactive cannabinoid acid

Lyme Disease

Antibacterial activity of D9_tetrahydrocannabinol and cannabidiol
Antimicrobial Activity of Cannabis sativa L.
Antibacterial Cannabinoids from Cannabis sativa- A Structure-Activity Study
Extraction of cannabinoids from cannabis sativa L plant and its potential antimicrobial activity
Essential oils of different cultivars of Cannabis sativa L. and their antimicrobial activity
In vitro antibacterial activity of Cannabis sativa leaf extracts to some selective pathogenicbacterial strains

Memory

Cannabinoid facilitation of fear extinction memory recall in humans
Impact of cannabidiol on the acute memory and psychotomimetic effects of smoked cannabis- naturalistic study
Keep off the grass Cannabis, cognition and addiction
Non-acute (residual) neurocognitive effects of cannabis Use- A meta-analytic study
On Disruption of Fear Memory by Reconsolidation Blockade- Evidence from Cannabidiol Treatment
Tolerance to the memory disruptive effects of cannabinoids involves adaptation by hippocampal neurons.
The cannabinoid receptor agonist WIN 55-212-2 facilitates the extinction of contextual fear memory and spatial memory in rats

Mental Illness

Adolescent Exposure to Chronic Delta-9-Tetrahydrocannabinol Blocks Opiate Dependence in Maternally Deprived Rats
B-Caryophyllene, a CB2 receptor agonist produces multiple behavioral changes relevant to anxiety and depression in mice
Brain CB2 Receptors- Implications for Neuropsychiatric Disorders
CB1 cannabinoid receptor stimulation during adolescence impairs the maturation of GABA function in the adult rat prefrontal cortex
Cortical glutamic acid decarboxylase 67 deficiency results in lower cannabinoid 1 receptor messenger RNA expression- implications for schizophrenia
Cannabidiol, neuroprotection and neuropsychiatric disorders
Cannabidiol for the treatment of psychosis in Parkinson's disease
Cannabidiol, a Nonpsychotropic Component of Cannabis, Inhibits Cue-Induced Heroin Seeking and Normalizes Discrete Mesolimbic Neuronal Disturbances
Cannabidiol as a potential treatment for psychosis
Cannabinoids in bipolar affective disorder- a review and discussion of their therapeutic potential
Cannabidiol, a Cannabis sativa constituent, as an antipsychotic drug
Cannabidiol enhances anandamide signaling and alleviates psychotic symptoms of schizophrenia
Cannabis as a substitute for alcohol and other drugs
Cannabidiol reverses MK-801-induced disruption of prepulse inhibition in mice
Cannabidiol reverses the mCPP-induced increase in marble-burying behavior
Distinct Neurobehavioural Effects of Cannabidiol in Transmembrane Domain Neuregulin 1 Mutant Mice
Effects of cannabinoid drugs on the deficit of prepulse inhibition of startle in an animal model of schizophrenia- the SHR strain
Effects of cannabidiol on schizophrenia-like symptoms in people who use cannabis
Influence of Treatment of Tourette Syndrome with D9-Tetrahydrocannabinol (D9-THC) on Neuropsychological Performance
Joint Effects- A Pilot Investigation of the Impact of Bipolar Disorder and Marijuana Use on Cognitive Function and Mood
Long term marijuana users seeking medical cannabis in California (2001–2007)- demographics, social characteristics, patterns of cannabis and other drug use of 4117 applicants
Multiple mechanisms involved in the large-spectrum therapeutic potential of cannabidiol in psychiatric disorders
Motor effects of delta 9 THC in cerebellar Lurcher mutant mice
Neural basis of anxiolytic effects of cannabidiol (CBD) in generalized social anxiety disorder_ a preliminary report - ResearchGate
Opposite Effects of D-9-Tetrahydrocannabinol and Cannabidiol on Human Brain Function and Psychopathology
Progress in Neuro-Psychopharmacology & Biological Psychiatry
Therapeutical use of the cannabinoids in psychiatry
The anxiolytic effect of cannabidiol on chronically stressed mice depends on hippocampal neurogenesis- involvement of the endocannabinoid system
The Development of Cannabidiol as a Psychiatric Therapeutic- A Review of Its Antipsychotic Efficacy and Possible Underlying Pharmacodynamic Mechanisms
The endocannabinoid system and emotional Processing- A pharmacological fMRI study with D9-tetrahydrocannabinol

Migraine

Activation of CB2 receptors as a potential therapeutic target for migraine- evaluation in an animal model
Comprehensive Review of Medicinal Marijuana, Cannabinoids, and Therapeutic Implications in Medicine and Headache- What a Long Strange Trip It’s Been
Clinical Endocannabinoid Deficiency (CECD)- Can this Concept Explain Therapeutic Benefits of Cannabis in Migraine, Fibromyalgia, Irritable Bowel Syndrome and other Treatment-Resistant Conditions
Clinical endocannabinoid deficiency (CECD) revisited- Can this concept explain the therapeutic benefits of cannabis in migraine, fibromyalgia, irritable bowel syndrome and other treatment-resistant co
Effects of anandamide in migraine- data from an animal model
Endocannabinoids in the Brainstem Modulate Dural Trigeminovascular Nociceptive Traffic via CB1 and “Triptan” Receptors- Implications in Migraine
The endocannabinoid system and migraine

Mitochondria

Cannabidiol Protects against Doxorubicin-Induced Cardiomyopathy by Modulating Mitochondrial Function and Biogenesis
Cannabidiol Targets Mitochondria to Regulate Intracellular Ca2 Levels
Mitochondria- a possible nexus for the regulation of energy homeostasis by the endocannabinoid system

MTHFR Gene Mutation

Anti-inflammatory effects of the cannabidiol derivative dimethylheptyl-cannabidiol – studies in BV-2 microglia and encephalitogenic T cells
Cannabidiol Protects against Doxorubicin-Induced Cardiomyopathy by Modulating Mitochondrial Function and Biogenesis
Cannabidiol Post-Treatment Alleviates Rat Epileptic-Related Behaviors and Activates Hippocampal Cell Autophagy Pathway Along with Antioxidant Defense in Chronic Phase of Pilocarpine-Induced Seizure
Cannabidiol affects the expression of genes involved in zinc homeostasis in BV-2 microglial cells
Mechanisms of cannabidiol neuroprotection in hypoxic-ischemic newborn pigs- Role of 5HT1A and CB2 receptors
Protective effect of cannabidiol against cadmium hepatotoxicity in rats
Therapeutic potential of cannabidiol against ischemia-reperfusion liver injury in rats

Multiple Sclerosis

A double-blind, randomized, placebo-controlled, parallel-group study of Sativex, in subjects with symptoms of spasticity due to multiple sclerosis
Cannabinoid Modulation of Neuroinflammatory Disorders
Cannabidiol provides long-lasting protection against the deleterious effects of inflammation in a viral model of multiple sclerosis- A role for A2A receptors
Cannabinoids for treatment of spasticity and other symptoms related to multiple sclerosis (CAMS study)- multicentre randomised placebo-controlled trial
Clinical experiences with cannabinoids in spasticity management in multiple sclerosis
Cannabinoids inhibit neurodegeneration in models of multiple sclerosis
Cannabinoids control spasticity and tremor in a multiple sclerosis model
Cannabinoids in multiple sclerosis (CAMS) study- safety and efficacy data for 12 months follow up
Cannabinoids in the management of spasticity associated with multiple sclerosis
Effects of cannabis on cognitive function in patients with multiple sclerosis
Efficacy, safety and tolerability of an orally administered cannabis extract in the treatment of spasticity in patients with multiple sclerosis- a randomized, double-blind, placebo-controlled, crossov
Interaction Between The Protective Effects Of Cannabidiol And Palmitoylethanolamide In Experimental Model Of Multiple Sclerosis In C57bl6 Mice
Psychopathological and cognitive effects of therapeutic cannabinoids in multiple sclerosis- a double-blind, placebo controlled, crossover study
Randomized, controlled trial of cannabis-based medicine in central pain in multiple sclerosis
Smoked cannabis for spasticity in multiple sclerosis- a randomized, placebo-controlled trial
Symptomatic therapy in multiple sclerosis- the role of cannabinoids in treating spasticity
Cannabinoids and multiple sclerosis
Sativex in the Management of Multiple Sclerosis-Related Spasticity- Role of the Corticospinal Modulation
THC-CBD Observational Study Data- Evolution of Resistant MS Spasticity and Associated Symptoms
Therapeutic Action of Cannabinoids in a Murine Model of Multiple Sclerosis
The cannabinoids an overview. Therapeutic implications in vomiting and nausea after cancer chemotherapy, in appetite promotion, in multiple sclerosis and in neuroprotection
The Endocannabinoid System Is Dysregulated in Multiple Sclerosis and in Experimental Autoimmune Encephalomyelitis
The effect of cannabis on tremor in patients with multiple sclerosis
Whole plant cannabis extracts in the treatment of spasticity in multiple sclerosis- a systematic review

Nausea

Cannabidiolic acid prevents vomiting in Suncus murinus and nausea-induced behaviour in rats by enhancing 5-HT1A receptor activation
Cannabinoid Regulation of Acute and Anticipatory Nausea
Cannabidiol, a non-psychotropic component of cannabis, attenuates vomiting and nausea-like behaviour via indirect agonism of 5-HT1A somatodendritic autoreceptors in the dorsal raphe nucleus
Interaction between non-psychotropic cannabinoids in marihuana- effect of cannabigerol (CBG) on the anti-nausea or anti-emetic effects of cannabidiol (CBD) in rats and shrews
Regulation of nausea and vomiting by cannabinoids
The cannabinoids an overview. Therapeutic implications in vomiting and nausea after cancer chemotherapy, in appetite promotion, in multiple sclerosis and in neuroprotection

Nervous System

Cannabinoid–Dopamine Interaction in the Pathophysiology and Treatment of CNS Disorders
Cannabinoid receptors 1 and 2 (CB1 and CB2), their distribution, ligands and functional involvement in nervous system structures — A short review
Direct suppression of autoreactive lymphocytes in the central nervous system via the CB2 receptor
Expression of central and peripheral cannabinoid receptors in human immune tissues and leukocyte subpopulations
Phytocannabinoids as novel therapeutic agents in CNS disorders
The effect of cannabichromene on adult neural stem-progenitor cells
Therapeutic Potential of Cannabinoids in CNS Disease

Neuro-protective and Neuro-generative

Activation of Type 1 Cannabinoid Receptor (CB1R) Promotes Neurogenesis in Murine Subventricular Zone Cell Cultures
An endogenous cannabinoid (2-AG) is neuroprotective after brain injury
Cannabinoids promote embryonic and adult hippocampus neurogenesis and produce anxiolytic- and antidepressant-like effects
Cannabidiol Reduces Aβ-Induced Neuroinflammation and Promotes Hippocampal Neurogenesis through PPARγ Involvement
Cannabidiol for neurodegenerative disorders- important new clinical applications for this phytocannabinoid
Cannabinoid receptor CB1 mediates baseline and activity-induced survival of new neurons in adult hippocampal neurogenesis
Cannabinoids and neuroprotection in basal ganglia disorders
Cannabidiol inhibits pathogenic T cells, decreases spinal microglial activation and ameliorates multiple sclerosis-like disease in C57BL_6 mice
CB1 Cannabinoid Receptors and On-Demand Defense Against Excitotoxicity
CB1 and CB2 Cannabinoid Receptor Antagonists Prevent Minocycline-Induced Neuroprotection Following Traumatic Brain Injury in Mice
Cannabidiol administration after hypoxia-ischemia to newborn rats reduces long-term brain injury and restores neurobehavioral function
Cannabidiol, neuroprotection and neuropsychiatric disorders
Cannabinoids inhibit neurodegeneration in models of multiple sclerosis
Cannabinoids in Neurodegenerative Disorders and Stroke-Brain Trauma- From Preclinical Models to Clinical Applications
Cannabinoids- Well-Suited Candidates for the Treatment of Perinatal Brain Injury
Cannabinoid CB2 receptor- a new target for controlling neural cell survival
Cannabidiol and (−)Δ9-tetrahydrocannabinol are neuroprotective antioxidants
Comparison of Cannabidiol, Antioxidants, and Diuretics in Reversing Binge Ethanol-Induced Neurotoxicity
D9-Tetrahydrocannabinol Prevents Methamphetamine-Induced Neurotoxicity
Endocannabinoids and traumatic brain injury
ENDOCANNABINOID SIGNALING IN NEUROTOXICITY AND NEUROPROTECTION
Endocannabinoids in the Retina- From Marijuana to Neuroprotection
Experimental autoimmune encephalomyelitis disrupts endocannabinoid-mediated neuroprotection
Long_term behavioral and biochemical effects of an ultra_low dose of D9_tetrahydrocannabinol (THC)- neuroprotection and ERK signaling
Molecular mechanisms of cannabinoid protection from neuronal excitotoxicity
Nonpsychoactive Cannabidiol Prevents Prion Accumulation and Protects Neurons against Prion Toxicity
Neuroprotective Effect of(−)Δ9-Tetrahydrocannabinol and Cannabidiol in N-Methyl-d-Aspartate-Induced Retinal Neurotoxicity
Neuroprotection by D9-Tetrahydrocannabinol, the Main Active Compound in Marijuana, against Ouabain-Induced In Vivo Excitotoxicity
Neuroprotective and Blood-Retinal Barrier-Preserving Effects of Cannabidiol in Experimental Diabetes
Neuroprotective antioxidants from marijuana
Neuroprotective effect of cannabidiol, a non-psychoactive component from Cannabis sativa, on beta-amyloid-induced toxicity in PC12 cells
Preclinical evaluation of SMM-189, a cannabinoid receptor 2-specific inverse agonist
Prospects for cannabinoid therapies in basal ganglia disorders
Protective effects of Δ9-tetrahydrocannabinol against N-methyl-D-aspartate-induced AF5 cell death
The cannabinoids an overview. Therapeutic implications in vomiting and nausea after cancer chemotherapy, in appetite promotion, in multiple sclerosis and in neuroprotection
The neuroprotective role of endocannabinoids against chemical-induced injury and other adverse effects
The Cannabinoid WIN55212-2 Promotes Neural Repair After Neonatal Hypoxia–Ischemia
The endocannabinoid system in normal and pathological brain ageing
The CB1 cannabinoid receptor signals striatal neuroprotection via a PI3K Akt mTORC1 BDNF pathway
The endocannabinoid 2-AG protects the blood–brain barrier after closed head injury and inhibits mRNA expression of proinflammatory cytokines
The endocannabinoid system as a target for the treatment of neurodegenerative disease
United States patent on cannabinoids as antioxidants and neuroprotectants

Neuropathy

An Exploratory Human Laboratory Experiment Evaluating Vaporized Cannabis in the Treatment of Neuropathic Pain from Spinal Cord Injury and Disease
Cannabinoids suppress inflammatory and neuropathic pain by targeting α3 glycine receptors
Cannabinoids delivery systems based on supramolecular inclusion complexes and polymeric nanocapsules for treatment of neuropathic pain
Cannabidiol inhibits paclitaxel-induced neuropathic pain through 5-HT1A receptors without diminishing nervous system function or chemotherapy efficacy
Cannabinoids for Neuropathic Pain
Smoked cannabis for chronic neuropathic pain- a randomized controlled trial

Non-Hodgkin's Lymphoma

Expression of cannabinoid receptors type 1 and type 2 in non-Hodgkin lymphoma- Growth inhibition by receptor activation

Nutrition

An Increase in the Omega-6-Omega-3 Fatty Acid Ratio Increases the Risk for Obesity
Dietary Omega-6-Omega-3 and Endocannabinoids- Implications for Brain Health and Diseases
Nutritional omega-3 deficiency abolishes endocannabinoid-mediated neuronal functions
The importance of the ratio of omega-6-omega-3 essential fatty acids
The Composition of Hemp Seed Oil and Its Potential as an Important Source of Nutrition

Obesity

An Increase in the Omega-6-Omega-3 Fatty Acid Ratio Increases the Risk for Obesity
Cannabinoid receptor 2 as anti-obesity target- inflammation, fat storage and browning modulation
Fatty Acid Modulation of the Endocannabinoid System and the Effect on Food Intake and Metabolism
Hind limb suspension and long-chain omega-3 PUFA increase mRNA endocannabinoid system levels in skeletal muscle
Pathophysiological role of host microbiota in the development of obesity
The cannabinoid Δ9-tetrahydrocannabivarin (THCV) ameliorates insulin sensitivity in two mouse models of obesity
The endocannabinoid system in obesity and type 2 diabetes

Obsessive Compulsive Disorder (OCD)

Cannabidiol reverses the mCPP-induced increase in marble-burying behavior
Facilitation of CB1 receptor-mediated neurotransmission decreases marble burying

Optic Function

Cannabinoid Receptors CB1 and CB2 Modulate the Electroretinographic Waves in Vervet Monkeys

Organ Transplants

Marijuana Use in Potential Liver Transplant Candidates

Pain

Assessing efficacy of non-opioid analgesics in experimental pain models in healthy volunteers- an updated review
An Exploratory Human Laboratory Experiment Evaluating Vaporized Cannabis in the Treatment of Neuropathic Pain from Spinal Cord Injury and Disease
Cannabinoids delivery systems based on supramolecular inclusion complexes and polymeric nanocapsules for treatment of neuropathic pain
Cannabinoids suppress inflammatory and neuropathic pain by targeting α3 glycine receptors
Cannabinoid–Opioid Interaction in Chronic Pain
Cannabidiol inhibits paclitaxel-induced neuropathic pain through 5-HT1A receptors without diminishing nervous system function or chemotherapy efficacy
Combined treatment with morphine and Δ9-tetrahydrocannibinol (THC) in rhesus monkeys- antinociceptive tolerance and withdrawal
Clinical Implications for Cannabinoid Use in the Rheumatic Diseases
Cannabinoid CB2 Receptors Regulate Central Sensitization and Pain Responses Associated with Osteoarthritis of the Knee Joint
Cannabis for the Management of Pain- Assessment of Safety Study (COMPASS)
Cannabinoids in the management of difficult to treat pain
Cannabinoid receptors and pain
Cannabinoids for treatment of chronic non-cancer pain
Cannabinoids for Neuropathic Pain
Gottschling cannabinoids with children pain spasticity pain treatment used and palliative medicine 2011 English translation DRAFT 28 Apr 11
Injury, Pain, and Prescription Opioid Use Among Former National Football League (NFL) Players
Hyperalgesia by low doses of the local anesthetic lidocaine involves cannabinoid signaling- An fMRI study in mice
Overcoming the Bell‐Shaped Dose‐Response of Cannabidiol by Using Cannabis Extract Enriched in Cannabidiol
Prescribing cannabis for harm reduction
Russo-Hohmann Role of cannabinoids in pain management from Deer 2013
Role of the Cannabinoid System in Pain Control and Therapeutic Implications for the Management of Acute and Chronic Pain Episodes
Sex differences in anti-allodynic, anti-hyperalgesic and anti-edema effects of Δ9-tetrahydrocannabinol in the rat
Survey Results of Pain Treatments in Adults with Cerebral Palsy
Synergistic affective analgesic interaction between delta-9-tetrahydrocannabinol and morphine
Stable dose cannabinoid medicine GW
Smoked cannabis for chronic neuropathic pain- a randomized controlled trial
The Endocannabinoid System, Cannabinoids, and Pain
Targeting CB2 receptors and the endocannabinoid system for the treatment of pain
The CB2 cannabinoid receptor-selective agonist O-3223 reduces pain and inflammation without apparent cannabinoid behavioral effects
The endogenous cannabinoid system and its role in nociceptive behavior
Therapeutic Benefits of Cannabis- A Patient Survey
The Pharmacologic and Clinical Effects of Medical Cannabis
Use of prescription pain medications among medical cannabis patients- comparisons of pain levels, functioning, and patterns of alcohol and other drug use
δ-Ctenitoxin-Pn1a, a Peptide from Phoneutria nigriventer Spider Venom, Shows Antinociceptive Effect Involving Opioid and Cannabinoid Systems, in Rats

Pancreatitis

Anti-Inflammatory Role of Cannabidiol and O-1602 in Cerulein-Induced Acute Pancreatitis in Mice
Cannabinoids Ameliorate Pain and Reduce Disease Pathology in Cerulein-Induced Acute Pancreatitis
Cannabinoids Reduce Markers of Inflammation and Fibrosis in Pancreatic Stellate Cells

Parkinson's

Cannabidiol for the treatment of psychosis in Parkinson's disease
Cannabidiol can improve complex sleep-related behaviours associated with rapid eye movement sleep behaviour disorder in Parkinson's disease patients- a case series
Effects of cannabidiol in the treatment of patients with Parkinson’s disease- An exploratory double-blind trial
GPR55 A therapeutic target for Parkinson's disease
Promising cannabinoid-based therapies for Parkinson’s disease- motor symptoms to neuroprotection
Self-Reported Efficacy of Cannabis and Other Complementary Medicine Modalities by Parkinson's Disease Patients in Colorado
Survey on Cannabis Use in Parkinson’s Disease- Subjective Improvement of Motor Symptoms
The influence of cannabinoids on generic traits of neurodegeneration
The CB1 cannabinoid receptor agonist reduces L-DOPA-induced motor fluctuation and ERK1-2 phosphorylation in 6-OHDA-lesioned rats

Patents

Patent- FORMULATION AND METHOD FOR INCREASING ORAL BIOAVAILABILITY OF DRUGS
United States patent application publication for phytocannabinoids in the treatment of cancer
United States patent on cannabinoids as antioxidants and neuroprotectants

Pets

Identification of an endogenous 2-monoglyceride, present in canine gut, that binds to cannabinoid receptors

Pharmacokinetics

Cannabis in the Arm- What Can we Learn from Intravenous Cannabinoid Studies
Cannabis as a substitute for prescription drugs- a cross-sectional study
Dietary fats and pharmaceutical lipid excipients increase systemic exposure to orally administered cannabis and cannabis-based medicines
Human Cannabinoid Pharmacokinetics
Patent- FORMULATION AND METHOD FOR INCREASING ORAL BIOAVAILABILITY OF DRUGS
Pharmacokinetics and metabolism of the plant cannabinoids, delta9-tetrahydrocannabinol, cannabidiol and cannabinol

Post Traumatic Stress Disorder (PTSD)

Association of the Cannabinoid Receptor Gene (CNR1) With ADHD and Post-Traumatic Stress Disorder
Changes of endocannabinoid plasma levels following type I trauma- A prospective pilot study
Cannabinoids Prevent the Effects of a Footshock Followed by Situational Reminders on Emotional Processing
Endocannabinoid concentrations in hair are associated with PTSD symptom severity
Elevated Brain Cannabinoid CB1 Receptor Availability in Posttraumatic Stress Disorder- A Positron Emission Tomography Study
On Disruption of Fear Memory by Reconsolidation Blockade- Evidence from Cannabidiol Treatment
PTSD Symptom Reports of Patients Evaluated for the New Mexico Medical Cannabis Program
Preliminary, open-label, pilot study of add-on oral D9-tetrahydrocannabinol in chronic post-traumatic stress disorder

Potential of whole plant vs. single compound model

Activity of cannabis in relation to its delta'-trans-tetrahydro-cannabinol content
An entourage effect_ inactive endogenous fatty acid glycerol esters enhance 2-arachidonoyl-glycerol cannabinoid activity
Cannabidiol Enhances the Inhibitory Effects of D9-Tetrahydrocannabinol on Human Glioblastoma Cell Proliferation and Survival
Cannabis and Cannabis Extracts- Greater Than the Sum of Their Parts
Overcoming the Bell‐Shaped Dose‐Response of Cannabidiol by Using Cannabis Extract Enriched in Cannabidiol
Russo_A tale of two cannabinoids
Taming THC- potential cannabis synergy and phytocannabinoid-terpenoid entourage effects

Pregnancy

A Longitudinal Study of Prenatal Marijuana Use
Cannabidiol changes P-gp and BCRP expression in trophoblast cell lines
Cannabis and Breastfeeding
Endocannabinoid System in First Trimester Placenta- Low FAAH and High CB1 Expression Characterize Spontaneous Miscarriage
Five-year follow-up of rural Jamaican children whose mothers used marijuana during pregnancy
Fetal Alcohol Spectrum Disorder- Potential Role of Endocannabinoids Signaling
Identifying Prenatal Cannabis Exposure and Effects of Concurrent Tobacco Exposure on Neonatal Growth
Lasting impacts of prenatal cannabis exposure and the role of endogenous cannabinoids in the developing brain
Ligand-receptor signaling with endocannabinoids in preimplantation embryo development and implantation
Maternal marijuana use during lactation and infant development at one year
Multiple Roles for the Endocannabinoid System During the Earliest Stages of Life- Pre- and Postnatal Development
Prenatal Marijuana Exposure and Neonatal Outcomes in Jamaica- An Ethnographic Study
The Endocannabinoid-CB Receptor System- Importance for development and in pediatric disease
The Endocannabinoid-CB Receptor System- Importance for development and in pediatric disease

Prostate Cancer

Cannabinoid receptor as a novel target for the treatment of prostate cancer
Cannabinoid Receptor Agonist-induced Apoptosis of Human Prostate Cancer Cells LNCaP Proceeds through Sustained Activation of ERK12 Leading to G1 Cell Cycle Arrest
Cannabinoid receptor-dependent and -independent anti-proliferative effects of omega-3 ethanolamides in androgen receptor-positive and -negative prostate cancer cell lines
Inhibition of human tumour prostate PC-3 cell growth by cannabinoids R( þ )-Methanandamide and JWH-015- Involvement of CB2
Non-THC cannabinoids inhibit prostate carcinoma growth in vitro and in vivo- pro-apoptotic effects and underlying mechanisms
Proapoptotic effect of endocannabinoids in prostate cancer cells
The role of cannabinoids in prostate cancer- Basic science perspective and potential clinical applications

Psoriasis

Cannabinoids inhibit human keratinocyte proliferation through a non-CB1-CB2 mechanism and have a potential therapeutic value in the treatment of psoriasis

Pulmonary Function

Association Between Marijuana Exposure and Pulmonary Function Over 20 Years
BRONCHODILATOR EFFECT OF D9-TETRAHYDROCANNABINOL
Cannabinoid effects on ventilation and breathlessness- a pilot study of efficacy and safety
Does smoking marijuana increase the risk of chronic obstructive pulmonary disease
Evaluation of Serum Cytokines Levels and the Role of Cannabidiol Treatment in Animal Model of Asthma
Effects of Marijuana Smoking on the Lung
Inhibition of guinea-pig and human sensory nerve activity and the cough reflex in guinea-pigs by cannabinoid (CB2) receptor activation
Monoacylglycerol Lipase (MAGL) Inhibition Attenuates Acute Lung Injury in Mice
Marijuana and chronic obstructive lung disease- a population-based study
Preclinical Assessment of Novel Therapeutics on the Cough Reflex- Cannabinoid Agonists as Potential Antitussives
The effects of marijuana exposure on expiratory airflow. A study of adults who participated in the U.S. National Health and Nutrition Examination Study

Safety

Cannabidiol Rescues Acute Hepatic Toxicity and Seizure Induced by Cocaine
CB1 Cannabinoid Receptors and On-Demand Defense Against Excitotoxicity
Cannabinoid effects on ventilation and breathlessness- a pilot study of efficacy and safety
Cannabidiol Attenuates Cisplatin-Induced Nephrotoxicity by Decreasing Oxidative-Nitrosative Stress, Inflammation, and Cell Death
Cannabinoids in multiple sclerosis (CAMS) study- safety and efficacy data for 12 months follow up
Cannabis for the Management of Pain- Assessment of Safety Study (COMPASS)
Comparison of Cannabidiol, Antioxidants, and Diuretics in Reversing Binge Ethanol-Induced Neurotoxicity
D9-Tetrahydrocannabinol Prevents Methamphetamine-Induced Neurotoxicity
Efficacy, safety and tolerability of an orally administered cannabis extract in the treatment of spasticity in patients with multiple sclerosis- a randomized, double-blind, placebo-controlled, crossov
ENDOCANNABINOID SIGNALING IN NEUROTOXICITY AND NEUROPROTECTION
Molecular mechanisms of cannabinoid protection from neuronal excitotoxicity
Nonpsychoactive Cannabidiol Prevents Prion Accumulation and Protects Neurons against Prion Toxicity
Neuroprotective Effect of(−)Δ9-Tetrahydrocannabinol and Cannabidiol in N-Methyl-d-Aspartate-Induced Retinal Neurotoxicity
Neuroprotection by D9-Tetrahydrocannabinol, the Main Active Compound in Marijuana, against Ouabain-Induced In Vivo Excitotoxicity
Neuroprotective effect of cannabidiol, a non-psychoactive component from Cannabis sativa, on beta-amyloid-induced toxicity in PC12 cells
Neuroprotective and Blood-Retinal Barrier-Preserving Effects of Cannabidiol in Experimental Diabetes
Protective effect of cannabidiol against cadmium hepatotoxicity in rats
Potentiation of Cannabinoid-Induced Cytotoxicity in Mantle Cell Lymphoma through Modulation of Ceramide Metabolism
Safety and efficacy of a novel cannabinoid chemotherapeutic, KM-233, for the treatment of high-grade glioma
Safety and Side Effects of Cannabidiol, a Cannabis sativa Constituent
Safety and Toxicology of Cannabinoids

Schizophrenia

A clinical comparison of schizophrenia with and without pre-onset cannabis use disorder- a retrospective cohort study using categorical and dimensional approaches
Cannabidiol enhances anandamide signaling and alleviates psychotic symptoms of schizophrenia
Cannabidiol reverses MK-801-induced disruption of prepulse inhibition in mice
Effects of cannabinoid drugs on the deficit of prepulse inhibition of startle in an animal model of schizophrenia- the SHR strain
Effects of cannabidiol on schizophrenia-like symptoms in people who use cannabis

Sickle-cell Disease

Cannabis use in sickle cell disease- a questionnaire study
Pain-related behaviors and neurochemical alterations in mice expressing sickle hemoglobin- modulation by cannabinoids

Skeletal System

Activation of Cannabinoid Receptor 2 Enhances Osteogenic Differentiation of Bone Marrow Derived Mesenchymal Stem Cells
Cannabinoids and the skeleton- From marijuana to reversal of bone loss
Cannabinoids and bone- endocannabinoids modulate human osteoclast function in vitro
Cannabinoid receptors and the regulation of bone mass
Effects of deleting cannabinoid receptor-2 on mechanical and material properties of cortical and trabecular bone
Peripheral cannabinoid receptor, CB2, regulates bone mass
Protective Effects of Cannabidiol on Lesion-Induced Intervertebral Disc Degeneration
Role of cannabinoids in the regulation of bone remodeling
THE ROLE OF TYPE 2 CANNABINOID RECEPTOR IN BONE METABOLISM
The cannabinoid CB1 receptor regulates bone formation by modulating adrenergic signaling