This special strain of hemp was developed by the Stanley family for the purposes of bringing the extremely beneficial cannabinoid, Cannabidiol or CBD, to patients who need the therapeutic benefits of the plant, without the psychoactivity accompanied by THC. There is a significant body of published research over the last 50 years, suggesting many potential benefits of CBD. These potential benefits include: anti-inflammatory, anti-tumoral, neuro-protective, neuro- genic, pain relieving, anti-psychotic, and anti-microbial. It is for these suggested properties that the Stanley’s were breeding for CBD. The anti-epileptic properties were known, but it was 5 year old Charlotte Figi who proved that this plant belonged first to patients with intractable epilepsy. Due to Charlotte’s remarkable recovery using the special hemp strain, it was only fitting to affectionately name the plant for her. Since that winter of 2012, when Charlotte began the treatment, more than 180 pediatric epilepsy patients have begun treatment. The Charlotte’s Web Hemp Oil is also known as “Alepsia”, a Latin term which means “belonging to seizures”. This Hemp Oil is created by the Stanley Brothers and tested a minimum of three times through the process to ensure that the exact number milligrams of each major cannabinoid are known. This allows for patients to titrate dosing to a therapeutic level and understand the individual dosing needs.
Many published studies have concluded that there is an apparent synergy or “entourage effect” between different phyto-cannabinoids and plant terpenes. Professor Mechoulam, the first to isolate and synthesize THC and CBD, stated in one of his published papers that,
This type of synergism may play a role in the widely held (but not experimentally based) view that in some cases plants are better drugs than the natural products isolated from them
One clinical study specific to convulsive disorders, conducted in 2003 by the Royal Pharmaceutical Society of Great Britain, found that a whole plant extract inhibited spasticity to a “comparable level”, while Cannabidiol alone was ineffective.
Whilst SCE (standardized cannabis extract) inhibited spasticity in the mouse model of MS to a comparable level, it caused a more rapid onset of muscle relaxation, and a reduction in the time to maximum effect compared with Delta9THC alone. The Delta9THC-free extract or cannabidiol (CBD) caused no inhibition of spasticity…..SCE was a more potent and again more rapidly-acting anticonvulsant than isolated Delta9THC, but in this model, the Delta9THC-free extract also exhibited anticonvulsant activity. Cannabidiol did not inhibit seizures
Centre for Pharmacognosy and Phytotherapy
Through retrospective case study, and now prospective study, Charlotte’s Web is proving more and more to have the combination of terpenes and cannabinoids to complete the “entourage effect” for the reduction of seizure activity for many patients.
The Stanley brothers are continually breeding new strains with many varieties of Cannabinoids with the hopes of achieving this compound synergy for many different medical conditions. While many of these strains do not qualify as hemp and will have to be grown under strict medical marijuana regulations, Charlotte’s Web is a true hemp strain. This has been a very misunderstood distinction by the general public. To understand better the differences between “Marijuana” and “Hemp”, click here.
Additional Resources http://en.wikipedia.org/wiki/Hemp
I know the discussion around this topic will no doubt get heated. I have felt that heat. But I feel a greater responsibility than ever to make sure those heated discussions are also well-informed by science.
Dr. Sanjay Gupta